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Immunologists today are interested in all of the diverse cell-types involved in host defense and have a deeper appreciation of the importance of innate immune mechanisms as a first line of protection against pathogens. This volume thus discusses the isolation and functional characterization of cells involved in innate immunity in mouse and man, including mast cells and eosinophils. Other focuses include natural killer cells, methods in statistics, in vivo imaging, genome engineering, and mutagenesis and culture that are adapted to the study of innate immunity in these hosts. These are complemented with a series of chapters dealing with alternative models: plants, worms, mosquitoes, flies, and fish. Together, these approaches and models are being used to dissect the complex interplay between hosts and pathogens and contribute to developing strategies to help fight infection. With chapters written by experts on the cutting-edge of this technology, Innate Immunity is an essential reference for immunologists, histologists, geneticists, and molecular biologists.

Natural immunity --- Immunology, Comparative --- Killer Cells, Natural --- Laboratory Manuals --- Genetic Techniques --- Immunologic Techniques --- Cytological Techniques --- Immunity, Innate --- Lymphocytes --- Publication Formats --- Clinical Laboratory Techniques --- Immunity --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Immune System Phenomena --- Leukocytes, Mononuclear --- Publication Characteristics --- Leukocytes --- Phenomena and Processes --- Blood Cells --- Immune System --- Cells --- Hemic and Immune Systems --- Blood --- Anatomy --- Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Natural immunity. --- Immunology, Comparative. --- Immunité naturelle --- Immunologie comparée --- EPUB-LIV-FT LIVBIOMO LIVMEDEC SPRINGER-B --- White Blood Corpuscles --- Blood Cells, White --- Blood Corpuscles, White --- White Blood Cells --- Blood Cell, White --- Blood Corpuscle, White --- Corpuscle, White Blood --- Corpuscles, White Blood --- Leukocyte --- White Blood Cell --- White Blood Corpuscle --- Mononuclear Leukocytes --- Leukocyte, Mononuclear --- Mononuclear Leukocyte --- Immune System Concepts --- Immune System Phenomenon --- Immune System Process --- Immune System Processes --- Concept, Immune System --- Concepts, Immune System --- Immune System Concept --- Phenomena, Immune System --- Phenomenon, Immune System --- Process, Immune System --- Processes, Immune System --- Anatomies --- Water --- Hemic System --- System, Hemic --- Cell --- Immune Systems --- System, Immune --- Systems, Immune --- Blood Corpuscles --- Blood Cell --- Blood Corpuscle --- Cell, Blood --- Cells, Blood --- Corpuscle, Blood --- Corpuscles, Blood --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Disease --- Diagnoses and Laboratory Examinations --- Diagnosis, Laboratory --- Laboratory Diagnosis --- Laboratory Examinations and Diagnoses --- Laboratory Techniques, Clinical --- Clinical Laboratory Technique --- Diagnoses, Laboratory --- Laboratory Diagnoses --- Laboratory Technique, Clinical --- Technique, Clinical Laboratory --- Techniques, Clinical Laboratory --- Lymphoid Cells --- Cell, Lymphoid --- Cells, Lymphoid --- Lymphocyte --- Lymphoid Cell --- Innate Immune Response --- Innate Immunity --- Immunity, Native --- Immunity, Natural --- Immunity, Non-Specific --- Resistance, Natural --- Immune Response, Innate --- Immune Responses, Innate --- Immunity, Non Specific --- Innate Immune Responses --- Native Immunity --- Natural Immunity --- Natural Resistance --- Non-Specific Immunity --- Cytologic Technics --- Cytological Technic --- Cytological Technics --- Cytological Technique --- Technic, Cytological --- Technics, Cytological --- Technique, Cytological --- Techniques, Cytological --- Cytologic Technic --- Technic, Cytologic --- Technics, Cytologic --- Cell Biology --- Antibody Dissociation --- Immunologic Technic --- Immunologic Technics --- Immunologic Technique --- Immunological Technics --- Immunological Techniques --- Technic, Immunologic --- Technics, Immunologic --- Technique, Immunologic --- Techniques, Immunologic --- Antibody Dissociations --- Dissociation, Antibody --- Dissociations, Antibody --- Immunological Technic --- Immunological Technique --- Technic, Immunological --- Technics, Immunological --- Technique, Immunological --- Techniques, Immunological --- Allergy and Immunology --- Genetic Technic --- Genetic Technics --- Genetic Technique --- Technic, Genetic --- Technics, Genetic --- Technique, Genetic --- Techniques, Genetic --- Genetics --- NK Cells --- Natural Killer Cells --- Cell, NK --- Cell, Natural Killer --- Cells, NK --- Cells, Natural Killer --- Killer Cell, Natural --- NK Cell --- Natural Killer Cell --- Comparative immunology --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- blood --- cytology --- immunology --- methods --- Immunology. --- Cytology. --- Human genetics. --- Medicine. --- Cell Biology. --- Human Genetics. --- Molecular Medicine. --- Cell biology --- Cellular biology --- Cytologists --- Immunobiology --- Life sciences --- Serology --- Heredity, Human --- Human biology --- Physical anthropology --- Health Workforce

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Si son rôle de bouclier est évoqué depuis des années, la réponse immunitaire antitumorale n'a pu être comprise que très récemment. Les armes extraordinairement précises que sont les thérapies ciblées offrent à la recherche de nouveaux angles d'attaque. La mise au point d'anticorps ciblant les points de contrôle du système immunitaire, ainsi que le développement des lymphocytes T exprimant des récepteurs d'antigène " chimériques ", modifient radicalement l'approche tactique. C'est une véritable lame de fond, ouvrant des perspectives inédites dans le contrôle de pathologies tumorales qui apparaissaient sans issue. La compréhension des mécanismes d'action de ces nouveaux outils thérapeutiques est essentielle pour mieux définir leurs indications et imaginer de nouvelles combinaisons, l'enjeu étant d'identifier la meilleure stratégie en fonction de la tumeur et du malade. Dans ce développement d'une médecine prédictive et personnalisée, l'immunothérapie antitumorale est devenue un atout majeur dans l'arsenal oncologique. L'objectif de ce livre est de fournir le bagage scientifique nécessaire pour mieux appréhender cette révolution, à l'origine d'une nouvelle discipline, l'immuno-oncologie. Sur ce terrain bouillonnant, peut-être comparable à l'arrivée de la pénicilline dans les années 1920, les auteurs présentent de façon didactique les outils et les concepts nouveaux qui viennent et viendront enrichir l'arsenal thérapeutique de nos oncologues. Le lecteur, cancérologue confirmé ou non, y trouvera un panorama complet et clair de l'immunothérapie d'aujourd'hui et de demain.

Immunotherapy. --- Neoplasms --- Immunothérapie anticancéreuse. --- Cancer --- therapy. --- Thérapeutique. --- Immunothérapie anticancéreuse. --- Thérapeutique. --- Immunothérapie anticancéreuse --- Neoplasms therapy --- Immunotherapy methods --- Immunotherapy --- therapy

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Malgré des progrès considérables et d'indéniables succès thérapeutiques, le cancer reste une des premières causes de mortalité. Issue de travaux de recherche fondamentale, la découverte des mécanismes qui contrôlent les réponses du système immunitaire a permis de concevoir de nouvelles approches thérapeutiques qui se sont révélées remarquablement efficaces sur des cancers jusqu'ici sans espoir. L'idée consiste à permettre aux défenses naturelles, que nous possédons tous, d'agir sur le cancer. Ce livre raconte l'histoire des recherches et des idées qui ont conduit à cette révolution médicale. De même qu'il y a eu un avant et un après la découverte des antibiotiques, on peut d'ores et déjà penser qu'il y aura un avant et un après l'immunothérapie des cancers.

Immunotherapy methods --- Neoplasms therapy

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Immunology. Immunopathology --- immunologie