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This book aims to clarify the potential association between frailty and cardiovascular disease in older people. Covering the biological as well as the clinical point of view, it allows researchers and clinicians to discover the significance of this topic. The contributions cover the most important aspects in the potential relationship between frailty and cardiovascular disease. In particular, authoritative authors in this field have clarified the definition and the epidemiology of frailty and cardiovascular disease in older people. A large part of the volume is dedicated to the biological mechanisms of frailty and cardiovascular disease, trying to find those in common between these two conditions. Since this book is dedicated to both researchers and clinicians, we have proposed some chapters to the importance of comprehensive geriatric assessment in the evaluation and treatment of cardiovascular diseases and frailty. In this regard, the importance of geriatric evaluation in cardiac surgery for older people is well covered. Finally, the importance of cardiac rehabilitation and physical exercise is summarized, being, actually, the most important treatments for both frailty and cardiovascular disease. Written by many well-known and widely published experts in their respective fields, this book will appeal to a wide readership such as researchers in the field and clinicians, especially suited in geriatric medicine and cardiology who, every day, face frail older patients. .

Geriatrics. --- Aging. --- Developmental biology. --- Geriatric nursing. --- Cardiology. --- Epidemiology. --- Geriatrics/Gerontology. --- Biogerontology. --- Geriatric Care. --- Diseases --- Public health --- Heart --- Internal medicine --- Gerontological nursing --- Nursing --- Development (Biology) --- Biology --- Growth --- Ontogeny --- Age --- Ageing --- Senescence --- Developmental biology --- Gerontology --- Longevity --- Age factors in disease --- Medicine --- Older people --- Physiological effect --- Health and hygiene --- Cardiovascular system --- Diseases. --- Cardiovascular diseases

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In this book, we have reported the most recent discoveries and updates regarding molecular pathways in osteoarthritis. In particular, the advances regarding therapeutical options, from a molecular point of view, are largely discussed.

Research & information: general --- Biology, life sciences --- osteoarthritis --- cartilage --- type II collagen --- matrix metalloproteinases --- MMP-13 --- regulation --- inhibitor --- NO synthase --- Interleukin-1β --- chondrocytes --- mitochondrial dysfunction --- mesenchimal stem cells --- chondrocytic commitment --- autophagy --- miRNAs --- hydrostatic pressure --- adipokines --- visfatin --- Wnt/β-catenin --- mechanical loading --- obesity --- microRNA --- oxidative stress --- vibrational spectroscopy --- near-infrared spectroscopy --- infrared spectroscopy --- Raman spectroscopy --- early diagnosis --- exercise --- physical activity --- nutraceuticals --- dietary supplements --- inflammation --- aging --- inflammaging --- osteochondral explant culture --- joint modelling --- pharmacological assay --- native tissue analysis --- hexosamine biosynthetic pathway --- cartilage trauma --- post-traumatic osteoarthritis --- O-GlcNAcylation --- glucosamine --- cell death --- therapy --- sex as a biological variable --- whole transcriptome sequencing --- molecules --- TGF-β --- SMAD2/3 signaling --- linker modifications --- meniscus --- proteomics --- MRM --- ECM --- celecoxib --- glucosamine sulfate --- chondroprotection --- NF-κB --- cytokines --- chemokines --- pathogenesis --- biomarker --- chondrocyte --- IL-1β --- IFNγ, IL-17 --- IL-4 --- RNA-Seq --- hypertrophy --- remodeling --- angiogenesis --- chondroitin --- collagen --- methylsulfonylmethane --- vitamin C --- vitamin D --- hyaluronic acid

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In this book, we have reported the most recent discoveries and updates regarding molecular pathways in osteoarthritis. In particular, the advances regarding therapeutical options, from a molecular point of view, are largely discussed.

Research & information: general --- Biology, life sciences --- osteoarthritis --- cartilage --- type II collagen --- matrix metalloproteinases --- MMP-13 --- regulation --- inhibitor --- NO synthase --- Interleukin-1β --- chondrocytes --- mitochondrial dysfunction --- mesenchimal stem cells --- chondrocytic commitment --- autophagy --- miRNAs --- hydrostatic pressure --- adipokines --- visfatin --- Wnt/β-catenin --- mechanical loading --- obesity --- microRNA --- oxidative stress --- vibrational spectroscopy --- near-infrared spectroscopy --- infrared spectroscopy --- Raman spectroscopy --- early diagnosis --- exercise --- physical activity --- nutraceuticals --- dietary supplements --- inflammation --- aging --- inflammaging --- osteochondral explant culture --- joint modelling --- pharmacological assay --- native tissue analysis --- hexosamine biosynthetic pathway --- cartilage trauma --- post-traumatic osteoarthritis --- O-GlcNAcylation --- glucosamine --- cell death --- therapy --- sex as a biological variable --- whole transcriptome sequencing --- molecules --- TGF-β --- SMAD2/3 signaling --- linker modifications --- meniscus --- proteomics --- MRM --- ECM --- celecoxib --- glucosamine sulfate --- chondroprotection --- NF-κB --- cytokines --- chemokines --- pathogenesis --- biomarker --- chondrocyte --- IL-1β --- IFNγ, IL-17 --- IL-4 --- RNA-Seq --- hypertrophy --- remodeling --- angiogenesis --- chondroitin --- collagen --- methylsulfonylmethane --- vitamin C --- vitamin D --- hyaluronic acid --- osteoarthritis --- cartilage --- type II collagen --- matrix metalloproteinases --- MMP-13 --- regulation --- inhibitor --- NO synthase --- Interleukin-1β --- chondrocytes --- mitochondrial dysfunction --- mesenchimal stem cells --- chondrocytic commitment --- autophagy --- miRNAs --- hydrostatic pressure --- adipokines --- visfatin --- Wnt/β-catenin --- mechanical loading --- obesity --- microRNA --- oxidative stress --- vibrational spectroscopy --- near-infrared spectroscopy --- infrared spectroscopy --- Raman spectroscopy --- early diagnosis --- exercise --- physical activity --- nutraceuticals --- dietary supplements --- inflammation --- aging --- inflammaging --- osteochondral explant culture --- joint modelling --- pharmacological assay --- native tissue analysis --- hexosamine biosynthetic pathway --- cartilage trauma --- post-traumatic osteoarthritis --- O-GlcNAcylation --- glucosamine --- cell death --- therapy --- sex as a biological variable --- whole transcriptome sequencing --- molecules --- TGF-β --- SMAD2/3 signaling --- linker modifications --- meniscus --- proteomics --- MRM --- ECM --- celecoxib --- glucosamine sulfate --- chondroprotection --- NF-κB --- cytokines --- chemokines --- pathogenesis --- biomarker --- chondrocyte --- IL-1β --- IFNγ, IL-17 --- IL-4 --- RNA-Seq --- hypertrophy --- remodeling --- angiogenesis --- chondroitin --- collagen --- methylsulfonylmethane --- vitamin C --- vitamin D --- hyaluronic acid

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This book provides family doctors with a wealth of evidence-based indications and tips regarding geriatric medicine and approaches for the management of older patients, to be applied in daily practice. After discussing old and new features of healthy ageing and the approaches required in Family Medicine Consultation, the text introduces key elements of geriatric medicine such as frailty, sarcopenia, and the comprehensive geriatric assessment (CGA), before describing a range of characteristics unique to older patients in different contexts, with a dedicated section on Palliative Care. The role of polypharmacy and the importance of quaternary prevention and deprescribing are also addressed. Finally, the book emphasizes both the importance of a humanistic approach in caring and the approach of research and meta-research in geriatrics. Though many texts explore the role of primary care professionals in geriatric medicine, the role of family doctors in older people care has not yet been clearly addressed, despite the growing burden of ageing, which has been dubbed the "silver tsunami." Family physicians care for individuals in the context of their family, community, and culture, respecting the autonomy of their patients. In negotiating management plans with their patients, family doctors integrate physical, psychological, social, cultural and existential factors, utilizing the knowledge and trust engendered by repeated visits. They do so by promoting health, preventing disease, providing cures, care, or palliation and promoting patient empowerment and self-management. This will likely become all the more important, since we are witnessing a global demographic shift and family doctors will be responsible for and involved in caring for a growing population of older patients. This book is intended for family medicine trainees and professionals, but can also be a useful tool for geriatricians, helping them to better understand some features of primary care and to more fruitfully interact with family doctors.

Sociology of health --- Epidemiology --- Geriatrics --- Social medicine --- Neuropathology --- Orthopaedics. Traumatology. Plastic surgery --- Human medicine --- bedrijfssoftware --- geneeskunde --- vertalen --- hersenen --- spoedgevallen --- geriatrie --- huisartsen --- epidemiologie --- EHBO (eerste hulp bij ongelukken)