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PURPOSE. This review aimed to identify all gene therapies currently in use or under clinical investigation for the treatment of any ocular disorder, and to provide a comprehensive overview of their safety and effectiveness. METHODS. The literature search was conducted in four databases (PubMed, Embase, Cochrane Central, and Web of Science Core Collection) and one clinical trial registry (ClinicalTrials.gov) and encompasses literature up to July 15, 2022. All systematic reviews, published clinical trial articles, and ongoing trials on gene therapy for ophthalmic disorders in humans were eligible for inclusion. RESULTS & DISCUSSION. A total of 71 full-text articles have been selected, including 4 systematic reviews and 67 published clinical trial articles reporting results from 41 trials. Most evidence is available on gene therapy for monogenic eye diseases, but the use of gene therapies for non-monogenic eye diseases is also being increasingly explored. Generally, all studies show positive safety results, with intraocular inflammation as a common but mostly transient adverse event. The identified phase III RCTs show positive efficacy results for LCA and LHON. Individual trial characteristics, efficacy and safety results are displayed in summary tables. A substantial heterogeneity with respect to trial design, safety and efficacy assessment and reporting is observed across the trials. Finally, 55 ongoing trials without published results have been identified, and their study characteristics are also presented in tabulated form. CONCLUSION. A variety of different gene therapy types are being developed for an increasing range of ocular disorders, all revealing a favorable safety profile, and in some cases also promising efficacy results. Randomized controlled trials with larger sample sizes are needed in the future, and should focus on reporting results in a standardized manner to enable future meta-analyses and the drawing of clear-cut conclusions.