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Dexamethasone or corticosteroids for postoperative pain management are broadly studied. Its postoperative analgesics effects have been demonstrated but evidence regarding the optimal dose is scarce. Some investigators indicate that high doses of corticosteroids might improve pain relief, but fear of side-effects limit their use. The goal of the present systematic review with meta-analysis of randomized-controlled trials was to asses efficacy and safety of high dose corticosteroids (≥15mg) for postoperative pain relief We consider our results of special interest for anaesthesiologist, surgeons and pain specialists since our observations can have a significant impact on the daily management of postoperative pain.