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This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients acquire a deeper understanding of the molecular basis of the pathophysiological processes.

Biophysics --- Biology --- Health & Biological Sciences --- Genetic disorders. --- NF-kappa B (DNA-binding protein) --- Immunoglobulin enhancer-binding protein --- Kappa B enhancer binding protein --- NF-kB (DNA-binding protein) --- Nuclear factor kappa B --- Transcription factor NF-kB --- Congenital diseases --- Disorders, Genetic --- Disorders, Inherited --- Genetic diseases --- Hereditary diseases --- Inherited diseases --- DNA-binding proteins --- Transcription factors --- Diseases --- Medical genetics --- Medicine. --- Human genetics. --- Biochemistry. --- Molecular Medicine. --- Human Genetics. --- Medical Biochemistry. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Composition --- Health Workforce --- Molecular biology. --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Molecular biochemistry --- Molecular biophysics --- Biomolecules --- Systems biology