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Consciousness remains one of the major unsolved problems in science. How do the feelings and sensations making up conscious experience arise from the concerted actions of nerve cells and their associated synaptic and molecular processes? Can such feelings be explained by modern science, or is there an entirely different kind of explanation needed? And how can this seemingly intractable problem be approached experimentally? How do the operations of the conscious mind emerge out of the specific interactions involving billions of neurons? This book seeks answers to these questions on the underlying assumption that consciousness can be understood using the intellectual potential of modern physics and other sciences. There are a number of theories of consciousness, some based on classical physics while others require the use of quantum concepts. The latter ones have drawn criticism from the parts of the scientific establishment while simultaneously claiming that classical approaches are doomed to failure. The contributing authors present a spectrum of opinions from both sides of this on-going scientific debate, allowing readers to decide for themselves which of the approaches are most likely to succeed.
Consciousness. --- Quantum theory. --- Biophysics. --- Biological physics --- Biology --- Medical sciences --- Physics --- Quantum dynamics --- Quantum mechanics --- Quantum physics --- Mechanics --- Thermodynamics --- Apperception --- Mind and body --- Perception --- Philosophy --- Psychology --- Spirit --- Self --- Neurosciences. --- Philosophy (General). --- Neurobiology. --- Physics. --- Quantum Physics. --- Philosophy, general. --- Physics, general. --- Natural philosophy --- Philosophy, Natural --- Physical sciences --- Dynamics --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Neurosciences --- Quantum physics. --- Philosophy. --- Mental philosophy --- Humanities
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This monograph addresses, in a systematic and pedagogical manner, the mathematical methods and the algorithms required to deal with the molecularly based problems of bioinformatics. The book will be useful to students, research scientists and practitioners of bioinformatics and related fields, especially those who are interested in the underlying mathematical methods and theory. Among the methods presented in the book, prominent attention is given to pair-wise and multiple sequence alignment algorithms, stochastic models of mutations, modulus structure theory and protein configuration analysis. Strong links to the molecular structures of proteins, DNA and other biomolecules and their analyses are developed. In particular, for proteins an in-depth exposition of secondary structure prediction methods should be a valuable tool in both molecular biology and in applications to rational drug design. The book can also be used as a textbook and for this reason most of the chapters include exercises and problems at the level of a graduate program in bioinformatics.
Bioinformatics --- Mathematics. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Data processing --- Life sciences. --- Bioinformatics. --- Proteomics. --- Genetics --- Human genetics. --- Life Sciences, general. --- Applications of Mathematics. --- Genetics and Population Dynamics. --- Human Genetics. --- Heredity, Human --- Human biology --- Physical anthropology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Molecular biology --- Proteins --- Math --- Science --- Biosciences --- Sciences, Life --- Applied mathematics. --- Engineering mathematics. --- Biomathematics. --- Mathematics --- Engineering --- Engineering analysis --- Mathematical analysis
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Physics, mathematics and chemistry all play a vital role in understanding the true nature and functioning of biological membranes, key elements of living processes. Besides simple spectroscopic observations and electrical measurements of membranes we address in this book the phenomena of coexistence and independent existence of different membrane components using various theoretical approaches. This treatment will be helpful for readers who want to understand biological processes by applying both simple observations and fundamental scientific analysis. It provides a deep understanding of the causes and effects of processes inside membranes, and will thus eventually open new doors for high-level pharmaceutical approaches towards fighting membrane- and cell-related diseases.
Biophysics. --- Membrane, Basement. --- Membrane. --- Cell membranes --- Membranes (Biology) --- Biological transport --- Biophysics --- Physical organic chemistry --- Biological Science Disciplines --- Physical Phenomena --- Tissues --- Anatomy --- Phenomena and Processes --- Natural Science Disciplines --- Disciplines and Occupations --- Biophysical Phenomena --- Membranes --- Physiology --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Cytology --- Biological membranes --- Biomembranes --- Biological physics --- Physics. --- Physical chemistry. --- Proteins. --- Cell membranes. --- Nanoscale science. --- Nanoscience. --- Nanostructures. --- Biological and Medical Physics, Biophysics. --- Membrane Biology. --- Physical Chemistry. --- Numerical and Computational Physics, Simulation. --- Nanoscale Science and Technology. --- Protein-Ligand Interactions. --- Biological interfaces --- Protoplasm --- Medical sciences --- Physics --- Chemistry, Physical organic. --- RNA-ligand interactions. --- Chemistry, Physical organic --- Chemistry, Organic --- Chemistry, Physical and theoretical --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Glycocalyces --- Biological physics. --- Cell membranes . --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Nanoscience --- Nano science --- Nanoscale science --- Nanosciences --- Science --- Natural philosophy --- Philosophy, Natural --- Physical sciences --- Dynamics --- Chemistry, Theoretical --- Physical chemistry --- Theoretical chemistry --- Chemistry --- Membranes cel·lulars
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This book is a collection of stories, reflections and advice written by proficient scientists. They address the question of what doing science means to them, and describe attitudes and working practices that have proved effective and rewarding. The book is aimed in particular at young people who are attracted by science or already undertaking undergraduate studies, and who are considering making science their long-term profession. It will also be helpful and revealing to early-career scientists who are searching for their own best route to success. The book serves as a platform for experienced scientists to describe their original inclination, how that subjective disposition found its expression in their way of doing science, whether their expectations were met, and what achievements they can claim. But it is not restricted to success: contributors also share details of the limitations and failures they have encountered. Last but not least they describe how they see science now, how they think it will be in the near future, and what advice they would give to the their much younger colleagues. Readers will appreciate the diversity of the individual paths shaped by different education, motivation, ambition, inclination, intuition, feeling, belief and eligibility. At the same time the stories confirm that science relies on a translation of this subjective level into an objective level, one that is shared and accepted by the international scientific community, and whose results are produced with a commonly accepted and fully rational scientific method of investigation.
Research—Methodology. --- Biology—Social aspects. --- Technology—Sociological aspects. --- Critical Thinking. --- Science—Moral and ethical aspects. --- Science—Social aspects. --- Research Skills. --- Societal Outreach of Biology. --- Science, Technology and Society. --- Science Ethics. --- Societal Outreach of Physics. --- Critical reflection --- Evaluative thinking --- Reflection (Critical thinking) --- Reflection process --- Reflective thinking --- Thinking, Critical --- Thinking, Reflective --- Thought and thinking --- Reflective learning --- Science --- Scientists. --- Vocational guidance. --- Professional employees --- Science as a profession --- Scientists --- Vocational guidance
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Volume 5 in the series Advances in Structural Biology is based upon a selection of articles presented at the Workshop on Molecular Bio-physics of the Cytoskeleton: Microtubule Formation, Structure, Function, and Interactions (August 18-22 1997 at the Banff Conference Centre in Banff, Alberta, Canada). Its main objective was to review the state-of-the-art of the field and stimulate a multidisciplinary investigation into the molecular biology of the cytoskeleton, which is amply manifested in the articles selected and published in this volume.
Cytology. --- Molecular structure. --- Structure, Molecular --- Chemical structure --- Structural bioinformatics --- Cell biology --- Cellular biology --- Biology --- Cells
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Volume 5 in the series Advances in Structural Biology is based upon a selection of articles presented at the Workshop on Molecular Bio-physics of the Cytoskeleton: Microtubule Formation, Structure, Function, and Interactions (August 18-22 1997 at the Banff Conference Centre in Banff, Alberta, Canada). Its main objective was to review the state-of-the-art of the field and stimulate a multidisciplinary investigation into the molecular biology of the cytoskeleton, which is amply manifested in the articles selected and published in this volume.
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Nanoneuroscience is the study of computationally relevant biomolecules found inside neurons. Because of recent technological advances at the nanometer scale, scientists have at their disposal increasingly better ways to study the brain and the biophysics of its molecules. This book describes how biomolecules contribute to the operations of synapses and perform other computationally relevant functions inside dendrites. These biomolecular operations considerably expand the brain-computer analogy - endowing each neuron with the processing power of a silicon-based multiprocessor. Amazingly, the brain contains hundreds of billions of neurons.
Cytology. --- Molecular neurobiology. --- Nanomedicine. --- Nanostructures. --- Molecular neurobiology --- Cytology --- Neurons --- Cytoskeleton --- Nanomedicine --- Nanostructures --- Mental Disorders --- Nervous System Diseases --- Psychiatry and Psychology --- Cells --- Nanotechnology --- Cytoplasmic Structures --- Diseases --- Nervous System --- Manufactured Materials --- Biomedical Technology --- Technology, Industry, and Agriculture --- Natural Science Disciplines --- Technology --- Anatomy --- Cytoplasm --- Miniaturization --- Disciplines and Occupations --- Technology, Industry, Agriculture --- Intracellular Space --- Cellular Structures --- Materials Science --- Neuroscience --- Technology - General --- Engineering & Applied Sciences --- Chemical & Materials Engineering --- Human Anatomy & Physiology --- Health & Biological Sciences --- Central nervous system --- Nanotechnology. --- Diseases. --- Materials science. --- Neurobiology. --- Biophysics. --- Biological physics. --- Biomedical engineering. --- Materials Science. --- Biophysics and Biological Physics. --- Biomedical Engineering. --- Molecular technology --- Nanoscale technology --- High technology --- Biological and Medical Physics, Biophysics. --- Biomedical Engineering and Bioengineering. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Neurosciences --- Biological physics --- Biology --- Medical sciences --- Physics
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