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The trace mineral selenium is still regarded as one of the most interesting and health-beneficial elements. In addition to the Editorial containing a dedication to Dr. Leopold Flohé, this Special Issue contains 13 research articles and 8 reviews, with over 120 different contributors covering many of the most important subjects concerning the study of selenium. The articles address both selenium as well as selenoproteins and their molecular roles, providing important considerations regarding this trace element’s impact on human and animal health and disease.

Research & information: general --- Biology, life sciences --- selenoproteome --- selenoprotein hierarchy --- nonradioactive isotopes --- SEC-ICP MS --- glutathione peroxidase --- thioredoxin reductase --- SECIS --- translation regulation --- autoimmune thyroid disease --- diabetes mellitus --- Graves' disease --- Hashimoto thyroiditis --- infection --- inflammation --- long-COVID --- rheumatoid arthritis --- selenoprotein P --- sepsis --- selenoprotein W --- thioredoxin --- 14-3-3 --- Akt --- cell death --- Selenof --- selenium --- selenoprotein --- colon cancer --- barrier integrity --- cardiovascular --- heart --- selenoproteins --- Keshan's Disease --- bacteria --- selenite --- selenium delivery system --- Trsp --- hypothalamus --- Agrp neuron --- sex differences --- diet-induced obesity --- leptin resistance --- macrophage --- differentiation --- redox signaling --- NRF2 --- NF-κB --- lipid mediators --- seleocysteine --- autoimmunity --- lymphocyte --- cadmium cytotoxicity --- cancer therapy --- cisplatin --- ICP-MS --- nonsynonymous mutation --- selenium homeostasis --- ZIP8 --- Trit1 --- isopentenylation --- tRNA[Ser]Sec --- selenocysteine --- genetic variance --- human disease --- selenophosphate synthetase --- endothelial cell --- reactive oxygen species --- cell growth --- angiogenesis --- SEPHS1 --- early embryogenesis --- embryonic lethality --- prostate --- cancer --- tumor suppressor --- selenoprotein deficiency --- SECISBP2 --- Sec-tRNA[Ser]Sec --- SEPSECS --- antioxidative defense --- autoantibody --- Hashimoto's thyroiditis --- trace element --- recoding --- SECIS-binding protein --- translation termination --- nonsense-mediated decay --- ribosome rescue --- health --- mouse models --- selenocysteine (Sec) --- virus --- viral --- antioxidant --- HIV --- HCV --- HBV --- coxsackie virus --- influenza --- HIV-1 --- viral infection --- SELENOS --- SELENOO --- primary T cells --- Jurkat --- SupT1 --- translational control --- selenoproteome --- selenoprotein hierarchy --- nonradioactive isotopes --- SEC-ICP MS --- glutathione peroxidase --- thioredoxin reductase --- SECIS --- translation regulation --- autoimmune thyroid disease --- diabetes mellitus --- Graves' disease --- Hashimoto thyroiditis --- infection --- inflammation --- long-COVID --- rheumatoid arthritis --- selenoprotein P --- sepsis --- selenoprotein W --- thioredoxin --- 14-3-3 --- Akt --- cell death --- Selenof --- selenium --- selenoprotein --- colon cancer --- barrier integrity --- cardiovascular --- heart --- selenoproteins --- Keshan's Disease --- bacteria --- selenite --- selenium delivery system --- Trsp --- hypothalamus --- Agrp neuron --- sex differences --- diet-induced obesity --- leptin resistance --- macrophage --- differentiation --- redox signaling --- NRF2 --- NF-κB --- lipid mediators --- seleocysteine --- autoimmunity --- lymphocyte --- cadmium cytotoxicity --- cancer therapy --- cisplatin --- ICP-MS --- nonsynonymous mutation --- selenium homeostasis --- ZIP8 --- Trit1 --- isopentenylation --- tRNA[Ser]Sec --- selenocysteine --- genetic variance --- human disease --- selenophosphate synthetase --- endothelial cell --- reactive oxygen species --- cell growth --- angiogenesis --- SEPHS1 --- early embryogenesis --- embryonic lethality --- prostate --- cancer --- tumor suppressor --- selenoprotein deficiency --- SECISBP2 --- Sec-tRNA[Ser]Sec --- SEPSECS --- antioxidative defense --- autoantibody --- Hashimoto's thyroiditis --- trace element --- recoding --- SECIS-binding protein --- translation termination --- nonsense-mediated decay --- ribosome rescue --- health --- mouse models --- selenocysteine (Sec) --- virus --- viral --- antioxidant --- HIV --- HCV --- HBV --- coxsackie virus --- influenza --- HIV-1 --- viral infection --- SELENOS --- SELENOO --- primary T cells --- Jurkat --- SupT1 --- translational control

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In the current edition, Selenium: Its Molecular Biology and Role in Human Health expands extensively on the previous editions providing readers with the most significant advances in the rapidly developing selenium field. Evidence from epidemiology and veterinary science supports the essential role of selenium in (human) health, but its split personality in both preventing and supporting cancer and also in promoting insulin resistance has become more clearly defined. The pivotal role of glutathione peroxidase 4 in a new process of programmed cell death, ferroptosis, brings new impetus to the field. Recently defined mutations in selenoprotein and biosynthesis factor genes have been identified in patients, and the resulting disorders further emphasize the significance of selenoproteins in human health. The mechanism of selenoprotein biosynthesis, the functions of selenoproteins, and the roles of dietary selenium have been further elucidated, and new regulatory mechanisms involving selenoproteins discovered. The book, therefore, covers the breadth of current selenium research. With up-to-date chapters written by leaders in their fields, it serves as an invaluable resource for novices as well as specialists.

Immunology. Immunopathology --- Nutritionary hygiene. Diet --- Pathological biochemistry --- Human medicine --- immunologie --- medische biochemie --- biochemie --- biomedische wetenschappen --- voedingsleer --- moleculaire biologie