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These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly what they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.

Neurosciences. --- Microglia. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Mesoglia --- Neuroglia --- Phagocytes --- Neurobiology. --- Immunology. --- Immunobiology --- Life sciences --- Serology --- Neurosciences

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Dit leerzame boek geeft antwoord op alle mogelijke vragen over plastic. Open de flapjes om te ontdekken wat, waarom, wanneer, waar, wie, welke...en hoe we allemaal een steentje kunnen bijdragen. (bron: covertekst)

English literature --- Didactics of social education --- lager onderwijs 1ste graad (doelgroep) --- informatieve jeugdliteratuur --- milieuverontreiniging --- milieubeheer --- milieueducatie --- afval --- Environmental protection. Environmental technology --- plastics --- recyclage

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Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveries have challenged the current view of microglia, showing their active and positive contribution to normal brain function. This Research Topic will review the novel physiological roles of microglia in the developing, mature and aging brain, under non-pathological conditions. In particular, this Research Topic will discuss the cellular and molecular mechanisms by which microglia contribute to the formation, pruning and plasticity of synapses; the maintenance of the blood brain barrier; the regulation of adult neurogenesis and hippocampal learning; and neuronal survival, among other important roles. Because these novel findings defy our understanding of microglial function in health as much as in disease, this Research Topic will also summarize the current view of microglial nomenclature, phenotypes, origin and differentiation, sex differences, and contribution to various brain pathologies. Additionally, novel imaging approaches and molecular tools to study microglia in their non-activated state will be discussed. In conclusion, this Research Topic seeks to emphasize how the current research in neuroscience is challenged by never-resting microglia.

Neuroscience --- Human Anatomy & Physiology --- Health & Biological Sciences

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Didactics of social education --- pop-up books

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Depuis quelques années, les enquêtes par sondage ont pris de l'ampleur, les méthodes n'ont cessé de se perfectionner. Cet ouvrage présente les développements les plus récents de la théorie de l'échantillonnage et de l'estimation en populations finies, notamment dans le cas d'études répétées dans le temps.Trois domaines sont particulièrement explorés : les enquêtes sociales, les enquêtes économiques et les enquêtes dans le domaine de la santé.

Public opinion polls --- Sampling (Statistics) --- Sondages d'opinion --- Echantillonnage (Statistique) --- Methodology --- Méthodologie --- Méthode statistique --- Statistical methods --- Enquête --- surveys --- Collecte de données --- data collection --- Échantillonnage --- Sampling --- Population humaine --- human population --- Opinion publique --- public opinion --- Méthodologie --- Methodology. --- Sampling (Statistics) - Methodology