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Prostate cancer is the most frequently diagnosed non-cutaneous malignancy in men, and the second leading cause of male cancer-related mortality in the United States.  The last decade has seen unprecedented progress in the detection, prognosis, treatment and prevention of prostate cancer. These advances have been driven largely by an increased understanding of the underlying biochemistry, molecular biology and genetics of the disease. New cell and animal models have been developed that recapitulate the natural progression of prostate cancer. New technologies have allowed scientists to view in detail the genomic, proteomic, metabolomics and other –omic universe of cancer cells and tissues. This has resulted in a greater understanding of the pathophysiology of the disease.

Prostate -- Cancer -- Diet therapy. --- Prostate -- Cancer -- Genetic aspects. --- Prostate -- Cancer -- Molecular aspects. --- Prostate --- Exocrine Glands --- Cell Physiological Processes --- Neoplastic Processes --- Prostatic Diseases --- Genital Neoplasms, Male --- Genitalia, Male --- Prostatic Secretory Proteins --- Tumor Markers, Biological --- Kallikreins --- Antigens, Neoplasm --- Biochemical Processes --- Proteins --- Seminal Plasma Proteins --- Genital Diseases, Male --- Neoplasms --- Biochemical Phenomena --- Biological Markers --- Pathologic Processes --- Genitalia --- Serine Endopeptidases --- Tissues --- Cell Physiological Phenomena --- Chemical Processes --- Antigens --- Amino Acids, Peptides, and Proteins --- Urogenital Neoplasms --- Neoplasms by Site --- Phenomena and Processes --- Chemical Phenomena --- Male Urogenital Diseases --- Biological Factors --- Endopeptidases --- Urogenital System --- Anatomy --- Diseases --- Chemicals and Drugs --- Serine Proteases --- Pathological Conditions, Signs and Symptoms --- Peptide Hydrolases --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Signal Transduction --- Prostatic Neoplasms --- Neoplasm Proteins --- Prostate-Specific Antigen --- Cell Transformation, Neoplastic --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Genetics. --- Cancer. --- Medicine. --- Cancer research. --- Medical biochemistry. --- Proteins. --- Cell biology. --- Systems biology. --- Biological systems. --- Biomedicine. --- Cancer Research. --- Medical Biochemistry. --- Cell Biology. --- Protein Science. --- Receptors. --- Biological Networks, Systems Biology. --- Biosystems --- Systems, Biological --- Biology --- System theory --- Systems biology --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Philosophy --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Oncology. --- Biochemistry. --- Cytology. --- Cell receptors. --- Systems Biology. --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Tumors --- Composition --- Proteins .

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This book serves as a tribute to the work of the many investigators who have attempted to understand the role of the androgen receptor (AR) in the development and progression of prostate cancer. The relationship between prostate cancer and androgen status was initially appreciated in the late 1800's, and then awareness reawakened in the 1940's by the studies of Charles Huggins and colleagues, for which the Nobel prize was awarded in 1966. The purpose of this book is to provide an up to date review of the molecular and cellular aspects of androgen action in prostate cancer. It includes an overview of the role of androgens in the development of the normal prostate and progression of prostate cancer. Our understanding of androgen metabolism and efforts to target androgen metabolism in the prevention and treatment of prostate cancer is presented. Androgen receptor structure/function relationships and the role of co-regulators are defined. Ligand-independent activation of the androgen receptor and the role of the androgen receptor during progression to the castration recurrent phenotype are discussed. Androgen-regulated genes are elucidated and their roles during prostate cancer progression are defined. Finally, the androgen receptor is presented as a viable target for novel therapies. Together, these reviews should give the reader a comprehensive conceptual framework of androgen action in prostate cancer.

Immunology. Immunopathology --- Pharmacology. Therapy --- Oncology. Neoplasms --- Human genetics --- Medical microbiology, virology, parasitology --- immunologie --- medische microbiologie --- medische genetica --- farmacie --- farmacologie --- genetica --- virologie --- toxicologie --- oncologie

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This book effectively summarizes our knowledge of recent advances in prostate cancer. It focuses on our state-of-the-art understanding of risk factors, prevention, detection, prognosis and treatment of prostate cancer and identifies basic science findings that are being translated into clinical practice. In addition, the book singles out key areas of research that have potential for clinical translation. Both basic scientists and clinicians will be invited to provide up-to-date reviews in each area of prostate cancer. During the last decade the pace of clinical discovery and the scientific adv

Prostate --- Cancer. --- Cancer --- Diagnosis. --- Treatment.

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This book serves as a tribute to the work of the many investigators who have attempted to understand the role of the androgen receptor (AR) in the development and progression of prostate cancer. The relationship between prostate cancer and androgen status was initially appreciated in the late 1800's, and then awareness reawakened in the 1940's by the studies of Charles Huggins and colleagues, for which the Nobel prize was awarded in 1966. The purpose of this book is to provide an up to date review of the molecular and cellular aspects of androgen action in prostate cancer. It includes an overview of the role of androgens in the development of the normal prostate and progression of prostate cancer. Our understanding of androgen metabolism and efforts to target androgen metabolism in the prevention and treatment of prostate cancer is presented. Androgen receptor structure/function relationships and the role of co-regulators are defined. Ligand-independent activation of the androgen receptor and the role of the androgen receptor during progression to the castration recurrent phenotype are discussed. Androgen-regulated genes are elucidated and their roles during prostate cancer progression are defined. Finally, the androgen receptor is presented as a viable target for novel therapies. Together, these reviews should give the reader a comprehensive conceptual framework of androgen action in prostate cancer.

Immunology. Immunopathology --- Pharmacology. Therapy --- Oncology. Neoplasms --- Human genetics --- Medical microbiology, virology, parasitology --- immunologie --- medische microbiologie --- medische genetica --- farmacie --- farmacologie --- genetica --- virologie --- toxicologie --- oncologie