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This succinct resource provides an ideal balance of the biology and practical therapeutic strategies for classic and non-classic BCR-ABL-negative myeloproliferative neoplasms. Utilizing current World Health Organization nomenclature, classification, and diagnostic criteria, international experts have assembled to convey the most up-to-date knowledge in this rapidly evolving field. The opening chapters cover the diagnosis and classification, genetics, cytogenetic findings, and prognostic factors of MPNs. Further chapters explore therapies specific to the different disease entities, including polycythemia vera, essential thrombocytopenia, myelofibrosis, and eosinophilic disorders, and mastocytosis. Unique areas of discussion include JAK2 inhibitor therapy, hematopoietic stem cell transplantation, and blastic transformation. A valuable reference for practicing hematologists, this forefront book enriches our understanding of recent discoveries and their impact on conventional and investigational treatments.

Blood -- Diseases. --- Leukemia. --- Myeloproliferative disorders -- Pathophysiology. --- Myeloproliferative disorders -- Treatment. --- Myeloproliferative disorders. --- Myeloproliferative disorders --- Bone marrow --- Hematologic Neoplasms --- Bone Marrow Diseases --- Hematologic Diseases --- Neoplasms by Site --- Myelodysplastic-Myeloproliferative Diseases --- Bone Marrow Neoplasms --- Hemic and Lymphatic Diseases --- Neoplasms --- Diseases --- Medicine --- Health & Biological Sciences --- Pathology --- Tumors --- Myeloproliferative syndromes --- Tumors. --- Molecular aspects. --- Treatment. --- Tumours --- Myeloproliferative syndrome --- Medicine. --- Angiology. --- Hematology. --- Oncology. --- Medical biochemistry. --- Medicine & Public Health. --- Medical Biochemistry. --- Cysts (Pathology) --- Oncology --- Oncology  . --- Angiography. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Blood-vessels --- Diagnosis, Radioscopic --- Radiography, Medical --- Haematology --- Internal medicine --- Blood --- Composition --- Radiography --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry

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Oncology. Neoplasms --- Pathological haematology --- Human medicine --- geneeskunde --- oncologie --- hematologie

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Myeloproliferative neoplasms (MPNs) are clonal stem cell diseases that, under the World Health Organization classification, are subcategorized into eight clinicopathologic entities. The current book focuses on three of these categories: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. A number of important questions regarding the diagnosis, prognosis, and treatment of these diseases have arisen following the discovery of the JAK2 V617F mutation in the majority of patients with bcr/abl-negative MPNs.   This book comprises evidence-based reviews and expert consensus results. It offers comprehensive coverage of relevant laboratory and clinical advances and places great emphasis on the practical issues that challenge physicians in their daily practice. The main topics considered thus include contemporary diagnostic  approaches, the value and limitations of mutation screening for diagnostic and  prognostic purposes, risk stratification in terms of both survival and other  disease complications such as leukemic transformation and thrombosis, and  modern therapeutic strategies, including conventional drugs, allogeneic stem cell  transplantation, and experimental drugs still under study. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.

Oncology. Neoplasms --- Pathological haematology --- Human medicine --- geneeskunde --- oncologie --- hematologie