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This book provides an overview of the practical aspects of diffusion tensor imaging (DTI), from understanding the basis of the technique through selection of the right protocols, trouble-shooting data quality, and analyzing DTI data optimally. DTI is a non-invasive magnetic resonance imaging (MRI) technique for visualizing and quantifying tissue microstructure based on diffusion. The book discusses the theoretical background underlying DTI and advanced techniques based on higher-order models and multi-shell diffusion imaging. It covers the practical implementation of DTI; derivation of information from DTI data; and a range of clinical applications, including neurosurgical planning and the assessment of brain tumors. Its practical utility is enhanced by decision schemes and a fully annotated DTI brain atlas, including color fractional anisotropy maps and 3D tractography reconstructions of major white matter fiber bundles. Featuring contributions from leading specialists in the field of DTI, Diffusion Tensor Imaging: A Practical Handbook is a valuable resource for radiologists, neuroradiologists, MRI technicians, and clinicians.

Brain --- Diffusion tensor imaging. --- Magnetic resonance imaging. --- DTI (Diffusion tensor imaging) --- Magnetic resonance diffusion tensor imaging --- Diffusion magnetic resonance imaging --- Radiology, Medical. --- Neurology. --- Neurosciences. --- Neuroradiology. --- Diagnostic Radiology. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Medicine --- Neuropsychiatry --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Diseases --- Diffusion Tensor Imaging --- DTI MRI --- Diffusion Tensor MRI --- Diffusion Tensor Magnetic Resonance Imaging --- Diffusion Tractography --- Diffusion Tensor MRIs --- Imaging, Diffusion Tensor --- MRI, Diffusion Tensor --- Tractography, Diffusion --- Radiology. --- Neurology . --- Radiological physics --- Physics --- Radiation --- Neuroradiography --- Neuroradiology

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This book provides an overview of the practical aspects of diffusion tensor imaging (DTI), from understanding the basis of the technique through selection of the right protocols, trouble-shooting data quality, and analyzing DTI data optimally. DTI is a non-invasive magnetic resonance imaging (MRI) technique for visualizing and quantifying tissue microstructure based on diffusion. The book discusses the theoretical background underlying DTI and advanced techniques based on higher-order models and multi-shell diffusion imaging. It covers the practical implementation of DTI; derivation of information from DTI data; and a range of clinical applications, including neurosurgical planning and the assessment of brain tumors. Its practical utility is enhanced by decision schemes and a fully annotated DTI brain atlas, including color fractional anisotropy maps and 3D tractography reconstructions of major white matter fiber bundles. Featuring contributions from leading specialists in the field of DTI, Diffusion Tensor Imaging: A Practical Handbook is a valuable resource for radiologists, neuroradiologists, MRI technicians, and clinicians.

Physical methods for diagnosis --- MRI (magnetic resonance imaging) --- tumoren --- neurochirurgie

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De Engelse term “motor neuron disease” (MND) wordt meestal gebruikt om t e verwijzen naar een groep van neurodegeneratieve aandoeningen, waarbij dysfunctie en degeneratie v an het motorische systeem centraal staan. De meest voorkomende vorm (of fenotype) van MND is amyotrofe laterale sclerose (ALS), een aandoening w aarbij de motorneuronen in het ruggenmerg en de hersenstam (de perifere motorneuronen, PMN) en deze in de motor en premotor cortex (de centrale motorneuronen, CMN) progressief aftakelen en degenereren. Hierdoor verli ezen ALS patienten geleidelijk de controle over vrijwillige beweging. An dere aandoeningen die onder de noemer MND geplaatst kunnen worden zijn p rimaire laterale sclerose (PLS) en progressieve musculaire atrofie (PMA) , waarbij er respectievelijk enkel klinische evidentie is van aantasting van de CMN of van de PMN. Alhoewel al deze aandoeningen eerder zeldzaam voorkomen, is hun verloop snel progressief en onvermijdelijk fataal, met een ietwat mildere prognose voor PLS. In 5-10 % van alle ALS patiënten ligt een genetische afwijking aan de basi s van de ziekte. Voor alle andere ALS patienten, alsook voor PLS en PMA patienten, is de etiologie van hun aandoening nog on

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This thesis focuses on the cognitive and neuroanatomical aspects of reading related subskills (such as phonology, orthography, speech perception and auditory processing) and on its dysfunction in dyslexia. The most prominent etiological theory on dyslexia postulates that the reading problems result from a phonological deficit, more specifically a deficit in the representation, storage and/or retrieval of speech sounds. It has been suggested that this phonological deficit is secondary to a more basic auditory deficit, but despite substantial research effort, the nature of these auditory problems remains hotly debated. A first controversy concerns the extent to which auditory problems in dyslexics are speech-specific, namely whether they can be reduced to basic auditory processing problems or whether they are phonetic in origin. A second topic of debate concerns the extent to which the auditory problems are specific to the processing of rapidly changing temporal information or whether they encompass a broader range of complex spectrotemporal processing. To address both questions within one test paradigm, we created a categorical perception task using four continua of similar acoustic complexity: (1) a speech contrast exploiting temporal cues (/ba/-/da/), (2) a speech contrast defined by non-temporal spectral cues (/u/-/y/), (3) a non-speech temporal contrast (spectrally rotated /ba/-/da/), and (4) a non-speech non-temporal contrast (spectrally rotated /u/-/y/). This design was first applied in an adult sample of 31 normal and 31 dyslexic readers (manuscript 1), and later in a 11-year old sample of 25 normal and 13 dyslexic readers (manuscript 2). In both studies, dyslexic readers demonstrate a specific deficit in the /bA/-/dA/ and rotated /bA/-/dA/-condition, which indicates a deficit in processing rapidly changing auditory information which is not speech-specific. At the neural level, it might be that these temporal specific processing problems are rooted in a decreased myelination, since this is crucial for a fast transmission of action potentials. Diffusion Tensor Imaging (DTI) provides a unique tool to non-invasively measure white matter properties, reflecting indirectly the degree of myelination. In addition, DTI also enables a 3D-reconstruction of white matter connections which is of particular interest to reading since this involves a widespread network of distant brain regions. The most consistent finding across previous DTI studies is that white matter integrity in the left temporoparietal region relates to reading and is decreased in dyslexic readers (review and meta-analysis in manuscript 3). However, evidence is sparse on which white matter bundle corresponds to this and how it relates to reading underlying subskills. We therefore conducted a DTI-study in the 20 best normal reading and 20 poorest dyslexic reading adults of manuscript 1 to investigate specific white matter tracts in relation to phonological and orthographic processing (manuscript 4). Results indicate that dyslexic adults show a lower white matter integrity in the left dorsal arcuate fasciculus, which correlates with phonological processes, whereas no deficit is observed in the left ventral inferior-fronto-occipital-fasciculus, which relates to orthographic aspects of reading. Finally, in manuscript 5 we focus on white matter correlates of auditory temporal processing by linking the DTI-data to neurofunctional EEG-coherence measures of slow (i.e. 4Hz) and fast (i.e. 20Hz) modulations. Dyslexic readers display relative to normal readers a lower neurofunctional coherence for 20 Hz modulations as well as a decreased left lateralization of white matter integrity in the arcuate fasiculus and in the posterior part of the superior temporal gyrus. Interestingly, left lateralization in the latter white matter region correlates in typical readers with better coherence on the fast modulation (20 Hz) whereas this relation was opposite in dyslexic readers. To conclude, at the cognitive level our dyslexic participants displayed specific problems in processing rapidly changing auditory information, which might correspond at the neural level to a decreased left dominance of white matter integrity in the auditory and language regions. The well known phonological problems of dyslexic readers seem to be reflected in a lower white matter integrity of the left arcuate fasciculus, whereas the inferior-fronto-occipital-fasciculus, involved in orthographic processing, is intact in dyslexic adults.

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