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This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.

Chemotherapy. --- Physiology, Pathological. --- Medicine --- Health & Biological Sciences --- Cardiovascular Diseases --- Pharmacy, Therapeutics, & Pharmacology --- Hypertension. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Blood pressure, High --- High blood pressure --- Vascular hypertension --- Medicine. --- Laboratory medicine. --- Molecular biology. --- Pharmaceutical technology. --- Internal medicine. --- Respiratory organs --- Biomedicine. --- Pharmacology/Toxicology. --- Pharmaceutical Sciences/Technology. --- Internal Medicine. --- Pneumology/Respiratory System. --- Laboratory Medicine. --- Molecular Medicine. --- Diseases. --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Blood circulation disorders --- Physiological effect --- Toxicology. --- Pneumology. --- Medical laboratories. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Medicine, Internal --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Health Workforce --- Respiratory organs—Diseases. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis

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• Reference Manager
• EndNote
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This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.

Molecular biology --- Physiology of the respiratory system --- Toxicology --- Pharmacology. Therapy --- Semiology. Diagnosis. Symptomatology --- Pathological biochemistry --- Pathology of the respiratory system --- Human medicine --- klinische chemie --- medische biochemie --- klinische laboratoria --- medische laboratoriumtechnologie --- farmacologie --- biochemie --- biomedische wetenschappen --- geneeskunde --- multimedia --- toxicologie --- pneumologie --- moleculaire biologie

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After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.

Molecular biology --- Human biochemistry --- Human physiology --- Pharmacology. Therapy --- Pathological biochemistry --- farmacie --- farmacologie --- biochemie --- toxicologie --- fysiologie --- moleculaire biologie