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Foreword written by Samuel A. Wells, Jr., MD Professor of Surgery Duke University Medical Center, Durham, NC According to the American Cancer Society, about 1 million persons in the United States will be diagnosed with solid cancer every year. About 50% of them will be potentially cured by surgery. The other half of the population may develop metastatic cancer. To date, there is no systemic treatment available to cure metastatic cancer. Therefore, cancer clinical trials are critical to evaluate reliable treatment modalities against metastatic cancer. Likewise, adjuvant trials are needed to prevent high risk patients from developing recurrence following definitive surgical resection of their cancer. Only about 3-5% of the adult cancer patients are enrolled in clinical trials. When the pediatric cancer clinical trial groups were able to accrue over 40 percent of eligible patients to their clinical trials, significant impact was made on the survival of these pediatric cancer patients. However, multiple barriers exist to block adult cancer patients from entering into clinical protocols. The ever-changing regulations for clinical trials and the ethical dilemma of treating cancer patients as subjects have made it ever so difficult for the principal investigators to conduct clinical research, especially when they are often ill-informed of the complex nature of the regulations and over-worked. Therefore, cancer clinical trials are at a critical junction. The objective of this book is to bring the issues of cancer clinical trials into focus so that proactive strategies may be developed to make such trials more user-friendly. Ultimately, the cancer patients will be benefited. "Clinical trials remain the most important vehicle for improving the care of cancer patients. This text presents the fundamental components and challenges involving clinical investigations. Leading experts discuss the critical issues covering the spectrum of important topics from planning to application." Steven T. Rosen, M.D. Series Editor.
Cancer --- Clinical trials --- Research --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Oncology .
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Sentinel lymph node (SLN) procedures have opened a window of opportunity for the study of micrometastasis. In eighty percent (80%) of metastasis there lies an orderly pattern of progression via the lymphatic network, while 20% of the time systemic metastasis occurs, bypassing the lymphatic system. During the past two decades, significant progress has been achieved in understanding the anatomical, functional, cellular and molecular aspects of the lymphovascular system and the metastasis process. · Molecular imaging advances help to localize early cancers more precisely. · Current status of the immune responses in the draining lymph nodes against cancer is summarized. · New paradigms of early cancer growth, proliferation, overcoming apoptosis are exploited in the development of anticancer treatment. In this book, basic scientists and clinicians exchange ideas so that laboratory findings can be applied to clinical dilemmas, and clinical problems can be targeted for research in the laboratory. Series editor's comments: "Cancer metastasis remains the greatest challenge for oncologists. The role of the lymphovascular system is critical and a focus of intense investigations. This text covers a spectrum of relevant research and clinical issues that impact on our understanding of this process." Steven T. Rosen, MD Series Editor.
Lymphatic metastasis. --- Lymphatics --- Metastasis --- Cancer --- Oncology . --- Hematology. --- Internal medicine. --- Oncology. --- Internal Medicine. --- Medicine, Internal --- Medicine --- Haematology --- Internal medicine --- Blood --- Tumors --- Diseases
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Demography --- United Nations --- Population policy. --- Population. --- Population assistance. --- Public Policy. --- United Nations. --- ECWA --- ESCAP --- Economic and Social Commission for Asia and the Pacific --- Latin American Demographic Center --- UN --- UNHCR --- United Nations Children's Fund --- United Nations Educational, Scientific and Cultural Organization --- United Nations High Commissioner for Refugees (UNHCR) --- World Bank --- FAO, United Nations --- Food and Agricultural Organization, United Nations --- UNESCO --- UNICEF --- Migration Policy --- Population Policy --- Social Protection --- Social Policy --- Migration Policies --- Policies, Migration --- Policies, Population --- Policies, Public --- Policies, Social --- Policy, Migration --- Policy, Population --- Policy, Public --- Policy, Social --- Population Policies --- Protection, Social --- Public Policies --- Social Policies --- Policy Making --- Social Control, Formal --- School Age Population --- School-Age Population --- Population, School Age --- Population, School-Age --- Populations --- Populations, School Age --- Populations, School-Age --- School Age Populations --- School-Age Populations --- Geografie --- Sociale geografie --- Bevolking. --- Population --- Population policy --- Public Policy --- Human population --- Human populations --- Population growth --- Populations, Human --- Economics --- Human ecology --- Sociology --- Malthusianism --- Population planning --- Social policy --- UNO --- Affirmative Action --- Action, Affirmative --- Naciones Unidas --- Nations Unies --- ONU --- Organisation des Nations Unies --- Organizat︠s︡ii︠a︡ Obʺedinennykh Nat︠s︡iĭ --- OON --- Vereinigte Nationen --- Umot ha-meʼuḥadot --- Organizacja Narodów Zjednoczonych --- ONZ --- Forente nasjoner --- Forenede nationer --- FN --- Förenta nationerna --- Gaertʻianebuli erebi --- Organização das Nações Unidas --- PBB --- Perserikatan Bangsa-Bangsa --- Kokusai Rengō --- Kokuren --- ENSZ --- Egyesült Nemzetek Szövetsége --- Birleșmiș Milletler Teșkilâtı --- Birlăşmiş Millătăr Tăşkilatı --- Birlashgan Millatlar Tashkiloti --- BMT --- YK --- Yhdistyneet kansakunnat --- OUN --- Organizacija Ujedinjenih Nacija --- NU --- Nazioni Unite --- OSN --- Organizace spojených národů --- Sāzmān-i Milal-i Muttafiq --- Bangsa² Bersatu --- Organización de las Naciones Unidas --- Ühinenud Rahvaste Organisatsioon --- ÜRO --- Organismos tōn Hēnōmenōn Ethnōn --- Umoja wa Mataifa --- Vereinten Nationen --- Vereinte Nationen --- Hayʼat al-Umam al-Muttaḥidah --- Verenigde Naties --- VN --- Organizația Națiunilor Unite --- Um --- Lien ho kuo --- OKB --- Organizata e Kombeve të Bashkuara --- Lian he guo --- U.N. --- Umam al-Muttaḥidah --- OĒE --- Hēnōmena Ethnē --- Organizácia Spojených Národov --- Sahaprachāchāt --- Națiunile Unite --- Organizat︠s︡ii︠a︡ na obedinenite nat︠s︡ii --- Organismos Hēnōmenōn Ethnōn --- Manẓūmat al-Umam al-Muttaḥidah --- AAN --- Arhanizatsyi︠a︡ Ab'i︠a︡dnanykh Natsyĭ --- Nações Unidas --- Orhanizat︠s︡ii︠a︡ Ob'i︠e︡dnanykh Nat︠s︡iĭ --- O.Ē.E. --- ʻOngkān Sahaprachāchāt --- Sjuninejal Konob'laq --- Sāzmān-i Milal-i Muttaḥid --- Milal-i Muttaḥid --- Nėgdsėn U̇ndėstniĭ Baĭguullaga --- NUB --- Rāshṭrasaṃgha --- או״מ --- أمم المتحدة --- الأمم المتحدة --- سازمان ملل متحد --- 国際連合 --- 联合囯 --- 聯合國 --- United Nations Organization --- Liên Hiệp Quó̂c --- Liên Hợp Quó̂c --- LHQ --- Kula Samagga --- YūʼAṅʻnʻ --- 联合国 --- Организация на обединените нации --- Организация Объединённых Наций
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Topology --- Topologie --- Congresses --- Congrès --- Congresses. --- Congrès
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664.661 --- Bread, rolls and buns exclusively or mainly from whole-grain wheat, wholemeal wheat or wheat flour. Wholemeal bread. White bread. Bread rolls. Currant buns etc. --- 664.661 Bread, rolls and buns exclusively or mainly from whole-grain wheat, wholemeal wheat or wheat flour. Wholemeal bread. White bread. Bread rolls. Currant buns etc. --- Baking --- Bread --- Breads --- Baked products --- Cooking (Bread) --- Cooking --- Bread, rolls and buns exclusively or mainly from whole-grain wheat, wholemeal wheat or wheat flour. Wholemeal bread. White bread. Bread rolls. Currant buns etc
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Environmental policy --- Pollution --- -Pollution --- 351.777 <4> --- Chemical pollution --- Chemicals --- Contamination of environment --- Environmental pollution --- Contamination (Technology) --- Asbestos abatement --- Bioremediation --- Environmental engineering --- Environmental quality --- Factory and trade waste --- Hazardous waste site remediation --- Hazardous wastes --- In situ remediation --- Lead abatement --- Pollutants --- Refuse and refuse disposal --- Environment and state --- Environmental control --- Environmental management --- Environmental protection --- State and environment --- Environmental auditing --- Wetgeving, reglementering i.v.m. milieubeheer, milieuhygiene, verontreiniging. Milieurecht. Milieuhygienerecht--zie ook {?502/504}; {?613/614}; {628}--Europa --- Environmental aspects --- Control --- Government policy --- 351.777 <4> Wetgeving, reglementering i.v.m. milieubeheer, milieuhygiene, verontreiniging. Milieurecht. Milieuhygienerecht--zie ook {?502/504}; {?613/614}; {628}--Europa --- Factory and trade waste. --- Législation --- Environmental policy - European Economic Community countries --- Pollution - European Economic Community countries --- Economic conditions --- Environments --- Noise reduction --- Political objectives --- Project planning --- Protection --- Research --- Wastes --- Water pollution
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