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Capsaicin is a principal pungent ingredient of red chili peppers, first isolated in the early nineteenth century by Christian Friedrich Bucholz. Widely consumed as a spice in South Asia and Latin America, Capsaicin has been used to treat pain and inflammation associated with a variety of diseases, including rheumatoid arthritis, diabetic neuropathy, post-masectomy pain, cluster headaches, and herpes zoster. Although recent studies have evaluated capsaicin as a novel anti-cancer agent, and mechanisms of capsaicin in preventing cancer have been described sporadically, the literature lacks a comprehensive review of capsaicin as a chemo-preventive agent. Role of Capsaicin in Oxidative Stress and Cancer offers a thorough exploration of the preventive and therapeutic effects of capsaicin in cancer models such as melanoma, pancreatic cancer, colon cancer, gastric cancer, breast cancer, prostate cancer, skin cancer, lung cancer, multiple myeloma and glioma.  The contributors, all internationally recognized researchers, identify various molecular and cellular targets of capsaicin, and show the critical role of mitochondria in capsaicin-mediated therapeutic effects. Readers will learn how capsaicin prevents or may treat cancer, how different cells respond to capsaicin, how environmental carcinogen-induced carcinogenesis can be prevented by capsaicin and the mechanism of oxidative stress caused by capsaicin.  This book will benefit medical students, oncologists and cancer researchers everywhere.

Catechols --- Protective Agents --- Polyunsaturated Alkamides --- Solanaceous Alkaloids --- Diseases --- Therapeutic Uses --- Fatty Acids, Monounsaturated --- Stress, Physiological --- Metabolism --- Fatty Acids, Unsaturated --- Physiological Processes --- Metabolic Phenomena --- Amides --- Alkaloids --- Physiological Effects of Drugs --- Phenols --- Alkenes --- Pharmacologic Actions --- Specialty Uses of Chemicals --- Heterocyclic Compounds --- Chemical Actions and Uses --- Phenomena and Processes --- Organic Chemicals --- Fatty Acids --- Physiological Phenomena --- Hydrocarbons, Acyclic --- Lipids --- Chemicals and Drugs --- Hydrocarbons --- Neoplasms --- Capsaicin --- Antineoplastic Agents --- Oxidative Stress --- Anticarcinogenic Agents --- Medicine --- Health & Biological Sciences --- Oncology --- Capsaicin. --- Oxidative stress. --- Axsain (Trademark) --- Capsaicine --- Capsidol (Trademark) --- Capsin (Trademark) --- Capzasin (Trademark) --- Gelcen (Trademark) --- Katrum (Trademark) --- NGX-4010 (Trademark) --- Qutenza (Trademark) --- Zacin (Trademark) --- Zostrix (Trademark) --- Medicine. --- Science. --- Cancer research. --- Gene expression. --- Pharmacology. --- Cell biology. --- Apoptosis. --- Biomedicine. --- Cancer Research. --- Science, general. --- Pharmacology/Toxicology. --- Gene Expression. --- Cell Biology. --- Oxidation-reduction reaction --- Stress (Physiology) --- Analgesics --- Capsaicinoids --- Oncology. --- Cytology. --- Toxicology. --- Science, Humanities and Social Sciences, multidisciplinary. --- Genes --- Genetic regulation --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Tumors --- Expression --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cell death --- Cancer research --- Physiological effect

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This book provides the reader with an overall understanding of the biology of pancreatic cancer, hereditary, complex signaling pathways and alternative therapies. The book explains nutrigenomics and epigenetics mechanisms such as DNA methylation, which may explain the etiology or progression of pancreatic cancer. Book also summarizes the molecular control of oncogenic pathways such as K-Ras and KLF4. Since pancreatic cancer metastasizes to vital organs resulting in poor prognosis, special emphasis is given to the mechanism of tumor cell invasion and metastasis. Role of nitric oxide and Syk kinase in tumor metastasis is discussed in detail. Prevention strategies for pancreatic cancer are also described. The molecular mechanisms of the anti-cancer effects of curcumin, benzyl isothiocyante and vitamin D are discussed in detail. Furthermore, this book covers the basic mechanisms of resistance of pancreatic cancer to chemotherapy drugs such as gemcitabine and 5-fluorouracil.

Oncology. --- Tumors --- Oncology

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