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Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 and 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology. Volume 1 is divided into two sections: “Malignant Transformation and Metastasis” and “Molecular Basis of Disease Therapy.” Volume 2 follows a similar structure and is divided into sections entitled “Kinases and Phosphate” and “Molecular Basis of Cell Death.” All of the contributors are at the forefront of scientific discovery, and the reviews they present systemically examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases.

Apoptosis. --- Pathology, Molecular. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Molecular pathology --- Molecular biology --- Physiology, Pathological --- Cell death

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This book covers all aspects of narrow band imaging (NBI), including research, general principles and diagnostic features in various ENT pathologies. In addition to highlighting the advantages of NBI over white light endoscopy for the detection of early cancers and lesions that are less than 1 cm in diameter, the book offers a step-by-step approach to help readers easily grasp various pathologies of the upper aerodigestive tract. It discusses both malignant and non-malignant aspects of NBI and provides extensive information on inflammatory lesions of the upper aerodigestive tract, including various clinical features of laryngopharyngeal reflux. Subsequent chapters cover the most difficult aspects of NBI in treated mucosa (post-chemo radiated), in which the potential recurrence of disease is a key question. It also addresses the limitations of NBI, including false positive and false negative cases. Given its scope, the book will benefit otolaryngologists, oncosurgeons, radiation oncologists and oral medicine practitioners, as well as graduate students of ENT, radiotherapy, oral medicine and oncosurgery.

Radiology, Medical. --- Otorhinolaryngology. --- Surgical oncology. --- Diagnostic Radiology. --- Surgical Oncology. --- Cancer --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Ear, nose, and throat diseases --- ENT diseases --- Otorhinolaryngology --- Medicine --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Excision --- Treatment --- Radiology. --- Radiological physics --- Physics --- Radiation

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General embryology. Developmental biology --- General microbiology --- Histology. Cytology --- Infectious diseases. Communicable diseases --- microbiologie --- besmettelijke ziekten --- cytologie --- embryologie (geneeskunde) --- histologie --- moleculaire biologie

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Chemoprevention of cancer has been the focus of intensive research for more than two decades. Epidemiological evidence has shown a small, but significant association between fruit and vegetable intake and a reduction in cancer risk.  Diet may account for about thirty five percent of cancer. Large claims have been made for the effectiveness of particular diets in determining one's risk of developing cancer, ranging from protection against cancer initiation, progression and metastasis. A wide array of dietary components has been demonstrated to be as effective in fighting off cancer. Towards an increased understanding of the nutrition, exercise and diet in preventing cancer or inhibiting its progression has led to the discovery and development of novel and effective drugs that regulate intracellular signaling network in the body.  This information will be very useful to explore novel and highly effective chemopreventive strategies for reducing the health burden of cancer. Hippocrates, who proclaimed 25 centuries ago, 'Let food be thy medicine and medicine be thy food'. They estimated that one third of all cancer cases could be prevented by a healthier diet; statements which are widely accepted in the scientific literature. This book covers the current state-of-the art knowledge on the impact of nutrition and diet with nutrigenetics, nutritional epigenomics, nutritional transcriptomics, proteomics, and metabolomics approach in cancer prevention and therapy.

Cancer -- Nutritional aspects. --- Medicine. --- Nutrition. --- Nutrition Therapy --- Investigative Techniques --- Drug Therapy --- Diseases --- Nutritional Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Physiological Phenomena --- Therapeutics --- Phenomena and Processes --- Diet --- Chemoprevention --- Neoplasms --- Diet Therapy --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Nutritional aspects. --- Alimentation --- Food --- Nutrition --- Health aspects --- Cancer research. --- Biomedicine. --- Biomedicine general. --- Cancer Research. --- Health --- Physiology --- Dietetics --- Digestion --- Food habits --- Malnutrition --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Oncology. --- Tumors --- Health Workforce --- Nutrition   . --- Biomedicine, general.

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Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 & 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology. Volume 1 is divided into two sections: "Malignant Transformation and Metastasis" and "Molecular Basis of Disease Therapy." Volume 2 follows a similar structure and is divided into sections entitled "Kinases and Phosphate" and "Molecular Basis of Cell Death." All of the contributors are at the forefront of scientific discovery, and the reviews they present systemically examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases.