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Sport-related concussion (SRC) has emerged as a significant health concern in professional sports, with millions of concussions occurring worldwide each year. Current return-to-play (RTP) protocols after SRC involve a multi-disciplinary approach with growing interest in genetic testing technology. Numerous studies have indicated that the gene Apolipoprotein E4 (APOE4) holds promise as a predictive factor for developing diseases subsequent to concussions and other traumatic brain injuries. Nevertheless, there is an ongoing and contentious debate surrounding the impact of SRC genetic testing on the RTP decision, encompassing concerns about the potential adverse effects on athletes, coaches and the entire sports community. Hence, the purpose of this paper is to explore the clinical and ethical components of SRC genetic testing and its potential integration into RTP protocols. As for the approach, the ACCE framework will be employed to assess the validity, utility, and ethical aspects of SRC genetic testing, including incidental findings and discrimination based on genetic information. It is arguable that the sport and medicine community need to consider the limitations of genetic testing and rely on comprehensive evaluations for RTP decisions while also prioritising athlete safety and fostering a responsible environment in professional sports through robust RTP protocols and educational programs.