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This book constitutes the proceedings of the 21st International Conference on Discovery Science, DS 2018, held in Limassol, Cyprus, in October 2018, co-located with the International Symposium on Methodologies for Intelligent Systems, ISMIS 2018. The 30 full papers presented together with 5 abstracts of invited talks in this volume were carefully reviewed and selected from 71 submissions. The scope of the conference includes the development and analysis of methods for discovering scientific knowledge, coming from machine learning, data mining, intelligent data analysis, big data analysis as well as their application in various scientific domains. The papers are organized in the following topical sections: Classification; meta-learning; reinforcement learning; streams and time series; subgroup and subgraph discovery; text mining; and applications.

Artificial intelligence. --- Data mining. --- Information storage and retrieva. --- Social sciences --- Artificial Intelligence. --- Data Mining and Knowledge Discovery. --- Information Storage and Retrieval. --- Computer Appl. in Social and Behavioral Sciences. --- Data processing. --- Information storage and retrieval. --- Algorithmic knowledge discovery --- Factual data analysis --- KDD (Information retrieval) --- Knowledge discovery in data --- Knowledge discovery in databases --- Mining, Data --- Database searching --- AI (Artificial intelligence) --- Artificial thinking --- Electronic brains --- Intellectronics --- Intelligence, Artificial --- Intelligent machines --- Machine intelligence --- Thinking, Artificial --- Bionics --- Cognitive science --- Digital computer simulation --- Electronic data processing --- Logic machines --- Machine theory --- Self-organizing systems --- Simulation methods --- Fifth generation computers --- Neural computers --- Information storage and retrieval systems. --- Automatic data storage --- Automatic information retrieval --- Automation in documentation --- Computer-based information systems --- Data processing systems --- Data storage and retrieval systems --- Discovery systems, Information --- Information discovery systems --- Information processing systems --- Information retrieval systems --- Machine data storage and retrieval --- Mechanized information storage and retrieval systems --- Computer systems --- Electronic information resources --- Data libraries --- Digital libraries --- Information organization --- Information retrieval --- Science --- Philosophy --- Application software. --- Application computer programs --- Application computer software --- Applications software --- Apps (Computer software) --- Computer software