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Angiogenesis is the growth of new blood vessels and is a key process which occurs during pathological disease progression. Excessive and damaging angiogenesis occurs in diseases such as cancer, diabetic retinopathies, age-related macular degeneration and atherosclerosis. In other diseases such as stroke and myocardial infarction, insufficient or improper angiogenesis results in tissue loss and ultimately higher morbidity and mortality. In this book we will begin by providing the reader with an overview of the process of angiogenesis including normal embryological development of blood vessels. The following chapters will each focus on a key angiogenic disease incorporating current scientific knowledge concerning the causes of activation of the “angiogenic switch”, pathological consequences, current treatment options and future perspectives. Where appropriate, results from pre-clinical trials, novel imaging modalities and nanotechnological approaches will be incorporated into these sections. Finally, since it is now believed that the process of angiogenesis operated via different signalling mechanisms in different vascular beds, we will discuss our current understanding of this phenomenon. The target audience for this book would include researchers in all the basic sciences; post-graduate students at Universities and Institutes; pharmaceutical industries; clinicians working in vascular biology or tissue imaging; pathologists; neurologists; tumour biologists; ophthalmologists and cardiologists.

Cardiovascular system -- Diseases -- Treatment. --- Neovascularization. --- Cardiovascular Physiological Processes --- Cardiovascular Diseases --- Diseases --- Cardiovascular Physiological Phenomena --- Neovascularization, Physiologic --- Vascular Diseases --- Circulatory and Respiratory Physiological Phenomena --- Phenomena and Processes --- Medicine --- Health & Biological Sciences --- Oncology --- Blood-vessels --- Treatment. --- Angiology --- Vascular system --- Vasculature --- Angiogenesis --- Medicine. --- Cancer research. --- Human genetics. --- Molecular biology. --- Neurosciences. --- Oncology. --- Biomedicine. --- Cancer Research. --- Molecular Medicine. --- Human Genetics. --- Cardiovascular system --- Growth --- Oncology  . --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Tumors --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research

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A wide range of research methods for the study of vascular development, from basic laboratory protocols to advanced technologies used in clinical practice, are covered in this work. A range of methodologies such as molecular imaging platforms and signalling analysis, along with tumour models are collated here. Four sections explore in vitro techniques, in vivo and ex vivo manipulations, imaging and histological analysis and other novel techniques in vascular biology. Readers will discover basic methodologies used for analysis of endothelial cell growth in vitro, including co-culture models of vessel formation. Authors also explore isolation and purification of cells and methods for analysis of data and visualization of localized vasculature with modern imaging platforms. Both animal models and human disease are covered in this work. Each chapter contains helpful sections on trouble shooting, additional notes and links, supporting the reader to carry out protocols. This book will appeal to students, researchers and medical professionals working in all vascular-linked fields such as cardio- and cerebro-vascular, cancer and dementia.

Biomedicine. --- Cancer Research. --- Biological Techniques. --- Laboratory Medicine. --- Medicine. --- Oncology. --- Medical laboratories. --- Cytology --- Médecine --- Cancérologie --- Research_xMethodology. --- Cytology_xResearch_xMethodology. --- Medicine --- Health & Biological Sciences --- Oncology --- Blood-vessels --- Physiology. --- Cancer research. --- Laboratory medicine. --- Biology --- Technique. --- Research --- Methodology. --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Tumors --- Biology—Technique. --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology --- Cancer research

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Immunology --- C-reactive protein --- cell signalling --- inflammation --- angiogenesis --- monomeric C-reactive protein

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Immunology --- C-reactive protein --- cell signalling --- inflammation --- angiogenesis --- monomeric C-reactive protein --- C-reactive protein --- cell signalling --- inflammation --- angiogenesis --- monomeric C-reactive protein