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The worldwide dissemination of antimicrobial-resistant bacteria, particularly those resistant to last-resource antibiotics, is a common problem to which no immediate solution is foreseen. In 2017, the World Health Organization (WHO) published a list of antimicrobial-resistant "priority pathogens", which include a group of microorganisms with high-level resistance to multiple drugs, named ESKAPE pathogens, comprising vancomycin-resistant Enterococcus faecium (VRE), methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA), extended spectrum β-lactamase (ESBL) or carbapenem-resistant Klebsiella pneumoniae, carbapenem-resistant Acinetobacter baumannii, carbapenem-resistant Pseudomonas aeruginosa and extended spectrum β-lactamase (ESBL) or carbapenem-resistant Enterobacter spp. These bacteria also have the ability to produce several virulence factors, which have a major influence on the outcomes of infectious diseases. Bacterial resistance and virulence are interrelated, since antibiotics pressure may influence bacterial virulence gene expression and, consequently, infection pathogenesis. Additionally, some virulence factors contribute to an increased resistance ability, as observed in biofilm-producing strains. The surveillance of important resistant and virulent clones and associated mobile genetic elements is essential to decision making in terms of mitigation measures to be applied for the prevention of such infections in both human and veterinary medicine, being also relevant to address the role of natural environments as important components of the dissemination cycle of these strains.

Research & information: general --- Biology, life sciences --- Microbiology (non-medical) --- biocide --- antibiotic resistance --- cross-resistance --- aminoglycoside --- adaptation --- biofilm --- pyruvate cycle --- mastitis --- staphylococci --- virulence factors --- genes --- antimicrobial resistance --- infant --- newborn --- bacteremia --- Gram-negative bacteria --- drug resistance --- microbial --- mortality --- microcosm --- Aeromonas --- climate change --- temperature --- pH --- water --- Acinetobacter baumannii --- virulence --- whole-genome sequencing --- international high-risk clones --- genomic epidemiology --- dogs --- Escherichia coli --- ESBL --- CTX-M-15 --- CTX-M-1 --- CTX-M-32 --- CTX-M-55 --- CTX-M-14 --- qAmpC --- CMY-2 --- camel --- domestic --- milk --- virulence genes --- extended-spectrum β-lactamases --- biofilm formation --- Pseudomonas aeruginosa --- carbapenem resistance --- KPC-2 --- plasmid --- diabetic foot infections --- Staphylococcus aureus --- subinhibitory concentrations --- virulence-related genes

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The worldwide dissemination of antimicrobial-resistant bacteria, particularly those resistant to last-resource antibiotics, is a common problem to which no immediate solution is foreseen. In 2017, the World Health Organization (WHO) published a list of antimicrobial-resistant "priority pathogens", which include a group of microorganisms with high-level resistance to multiple drugs, named ESKAPE pathogens, comprising vancomycin-resistant Enterococcus faecium (VRE), methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA), extended spectrum β-lactamase (ESBL) or carbapenem-resistant Klebsiella pneumoniae, carbapenem-resistant Acinetobacter baumannii, carbapenem-resistant Pseudomonas aeruginosa and extended spectrum β-lactamase (ESBL) or carbapenem-resistant Enterobacter spp. These bacteria also have the ability to produce several virulence factors, which have a major influence on the outcomes of infectious diseases. Bacterial resistance and virulence are interrelated, since antibiotics pressure may influence bacterial virulence gene expression and, consequently, infection pathogenesis. Additionally, some virulence factors contribute to an increased resistance ability, as observed in biofilm-producing strains. The surveillance of important resistant and virulent clones and associated mobile genetic elements is essential to decision making in terms of mitigation measures to be applied for the prevention of such infections in both human and veterinary medicine, being also relevant to address the role of natural environments as important components of the dissemination cycle of these strains.

Research & information: general --- Biology, life sciences --- Microbiology (non-medical) --- biocide --- antibiotic resistance --- cross-resistance --- aminoglycoside --- adaptation --- biofilm --- pyruvate cycle --- mastitis --- staphylococci --- virulence factors --- genes --- antimicrobial resistance --- infant --- newborn --- bacteremia --- Gram-negative bacteria --- drug resistance --- microbial --- mortality --- microcosm --- Aeromonas --- climate change --- temperature --- pH --- water --- Acinetobacter baumannii --- virulence --- whole-genome sequencing --- international high-risk clones --- genomic epidemiology --- dogs --- Escherichia coli --- ESBL --- CTX-M-15 --- CTX-M-1 --- CTX-M-32 --- CTX-M-55 --- CTX-M-14 --- qAmpC --- CMY-2 --- camel --- domestic --- milk --- virulence genes --- extended-spectrum β-lactamases --- biofilm formation --- Pseudomonas aeruginosa --- carbapenem resistance --- KPC-2 --- plasmid --- diabetic foot infections --- Staphylococcus aureus --- subinhibitory concentrations --- virulence-related genes

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This book explores the dynamics of the interaction between the development of creative industries and urban land use in Nanjing, a metropolis and a growth pole in the Yangtze River Delta. In the last two decades, China's economy has been undergoing dramatic growth. Yet, accompanying with China's economic success is the disturbing environmental deterioration and energy concerns. These issues together with the diminution of the advantage of low-cost labour force present many Chinese cities, particularly big cities specialising in manufacturing in the most developed regions, the urgency to find new approaches to "creative China". As an ancient city featured by abundance of cultural heritages and legacies of heavy industries, Nanjing has been striving for a decade to transform its economy towards a creative economy by cultivating creative industries. In parallel with the flourishing of creative industries are contest for land resources among different interest parties and restructuring of urban land use. Both are new challenges for urban planning. This complex process is examined in this book by an interdisciplinary approach which integrates GIS, ABM, questionnaire investigation and interview.

Geodesy. Cartography --- Environmental planning --- Geography --- geodesie --- GIS (geografisch informatiesysteem) --- reizen

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"The Routledge Handbook of Planning Research Methods is an expansive look at the traditions, methods, and challenges of research design and research projects in contemporary urban planning. Through case studies, an international group of researchers, planning practitioners, and planning academics and educators, all recognized authorities in the field, provide accounts of designing and implementing research projects from different approaches and venues. This book shows how to apply quantitative and qualitative methods to projects, and how to take your research from the classroom to the real world. The book is structured into sections focusing on Beginning planning research Research design and development Rediscovering qualitative methods New advances in quantitative methods Turning research into action With chapters written by leading scholars in spatial planning, The Routledge Handbook of Planning Research Methods is the most authoritative and comprehensive handbook on the topic, providing both established and ground breaking coverage of spatial planning research methods. The book is an invaluable resource for undergraduate and graduate level students, young professionals and practitioners in urban, regional, and spatial planning. "

urban development --- ruimtelijke ordening --- Environmental planning --- urbanisme --- research [function] --- stadsontwikkeling --- onderzoeksmethoden --- comprehensive plans [reports] --- City planning --- POLITICAL SCIENCE / Public Policy / Social Policy. --- Research. --- Research --- 711.4 --- Cities and towns --- Civic planning --- Land use, Urban --- Model cities --- Redevelopment, Urban --- Slum clearance --- Town planning --- Urban design --- Urban development --- Urban planning --- Land use --- Planning --- Art, Municipal --- Civic improvement --- Regional planning --- Urban policy --- Urban renewal --- Gemeentelijke planologie. Stadsplanning. Stedenbouw --- Government policy --- Management --- Ruimtelijke planning en ruimtelijk ontwerp --- Planningsmethodologie --- Planningsmethodologie. --- 711.4 Gemeentelijke planologie. Stadsplanning. Stedenbouw --- Ruimtelijke ordening --- wetenschappelijk onderzoeken --- Villes --- Methodology. --- Méthodologie. --- Recherche. --- Méthodologie.