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Book
ISBN: 1281953849 9786611953843 0387097899 0387097880 1441918876 Year: 2008 Publisher: New York, N.Y. : Austin, Tex. : Springer Science+Business Media ; Landes Bioscience,
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Shows that the structural similarity of the Multichain Immune Recognition Receptors (MIRRs) determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. This book provides the basis for existing and future therapeutic strategies targeting MIRRs.
Immune recognition. --- T cells --- Killer cells. --- Cellular signal transduction. --- Cell receptors. --- Receptors. --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- K cells --- Natural killer cells --- NK cells --- Immunocompetent cells --- Cell-mediated cytotoxicity --- T cell receptors --- T lymphocyte antigen receptors --- Cell receptors --- Antigen recognition --- Immunorecognition --- Recognition, Immune --- Immune response --- Immunospecificity --- Oncology . --- Medicine. --- Life sciences. --- Oncology. --- Biomedicine general. --- Life Sciences, general. --- Tumors --- Biosciences --- Sciences, Life --- Science --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biomedicine, general. --- Health Workforce
Book
ISBN: 9780387097893 Year: 2008 Publisher: New York NY Springer New York
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Immunological recognition is a central feature of the adaptive immunity of vertebrates. With the exception of agnathans, which developed an entirely distinct set of immunologically-specific molecules, all vertebrates use a recognition system based on what Achsah Keegan and I suggested in 1992 be termed multichain immune recognition receptors (MIRRs). MIRRs consist of ligand-binding molecules that are immunoglobulin supergene family members associated with signal transducers and enhancers in such a way as both insure precise ligand recognition, discrimination and ampHfication of the signal. Two of the prototypic sets of MIRRs, the T-cell and B-cell receptors, are among the most remarkable recognition molecules known. These are extraordinarily diverse molecules in which the range of ligands that can be potentially recognized prob ably exceeds the actual numbers of lymphocytes in the body. The discovery of the genetic basis of assembling these receptors and understanding how they bind to their cognate antigens are among the most stunning of scientific achievements. Yet these immensely specific binding chains (the heavy/light chain pair for immunoglobulin and the a/p chain pair for most T cells), when expressed as membrane molecules, have no obvious mechanism of signaling. For example, the |iH chain cytosolic do main consists of three amino acids (lysine-valine-lysine) and the L chain is not even embedded in the membrane. Furthermore, there is no known direct mechanism to propagate information from the binding domain of the B-cell or T-cell receptors to the membrane-proximal domains of the same chains.
Digital
ISBN: 9780387097893 Year: 2008 Publisher: New York, NY Springer New York
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