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Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in mo

Cancer -- Cytopathology. --- Cancer -- Molecular aspects. --- Cancer - Treatment. --- Cancer -- Treatment -- Data processing. --- Cell differentiation. --- Cell Differentiation. --- Cells - Growth. --- Cellular therapy. --- Drug targeting. --- Growth factors - Therapeutic use. --- Intercellular Signaling Peptides and Proteins - metabolism. --- Metastasis. --- Neoplasms - etiology. --- Neoplasms - therapy. --- Growth factors --- Cancer --- Cellular therapy --- Cell differentiation --- Cells --- Metastasis --- Biological Factors --- Peptides --- Cell Physiological Processes --- Metabolic Phenomena --- Proteins --- Diseases --- Receptors, Peptide --- Amino Acids, Peptides, and Proteins --- Cell Physiological Phenomena --- Phenomena and Processes --- Chemicals and Drugs --- Receptors, Cell Surface --- Membrane Proteins --- Intercellular Signaling Peptides and Proteins --- Neoplasms --- Cell Differentiation --- Receptors, Growth Factor --- Metabolism --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Oncology --- Therapeutic use --- Treatment --- Growth --- Cell receptors --- Physiological effect. --- Treatment. --- Motility. --- Cell motility --- Cell movement --- Cellular movement --- Motility of cells --- Biomechanics --- Cell physiology --- Cancer therapy --- Cancer treatment --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Cell fate specification --- Cell specification --- Differentiation of cells --- Fate specification of cells --- Specification of cells --- Morphogenesis --- Movement --- Therapy --- Differentiation --- Fate specification --- Specification

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Cancer --- Molecular aspects. --- Management. --- Treatment. --- Cancer therapy --- Cancer treatment --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Therapy

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Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so

Oncology. Neoplasms --- Cancer --- Molecular aspects. --- Genetic aspects. --- Treatment.

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Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information. * Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells * Examines the role of genetic recombination in cancer including cancer invasion and metastasis * Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers.

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Oncology. Neoplasms