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This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials – the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of "steroid-like" natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.

Chemistry. --- Organic chemistry. --- Chemical engineering. --- Medicinal chemistry. --- Organic Chemistry. --- Medicinal Chemistry. --- Industrial Chemistry/Chemical Engineering. --- Organic compounds --- Asymmetry (Chemistry) --- Synthesis. --- Molecular asymmetry --- Chemistry, Organic --- Chemistry, Synthetic organic --- Organic synthesis (Chemistry) --- Synthetic organic chemistry --- Synthesis --- Stereochemistry --- Chemistry, Organic. --- Biochemistry. --- Chemistry, Industrial --- Engineering, Chemical --- Industrial chemistry --- Engineering --- Chemistry, Technical --- Metallurgy --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Organic chemistry --- Composition --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry

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Civil rights --- Droits de l'homme

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Law

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Habeas corpus is everyone's 'get out of jail free' card. It is the legal remedy ensuring a person's release from prison or any other form of custody when the detention cannot be justified in law. This volume provides in-depth and critical analysis of the law behind this vital protection of liberty.

Habeas corpus --- Law - Non-U.S. --- Law, Politics & Government --- Law - Great Britain --- Civil rights --- Constitutional law --- Criminal procedure --- Detention of persons --- Extraordinary remedies --- Martial law --- Post-conviction remedies --- Writs

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Habeas corpus --- Liberty --- Liberté --- Civil rights --- Constitutional law --- Criminal procedure --- Detention of persons --- Extraordinary remedies --- Martial law --- Post-conviction remedies --- Writs