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The human genome encompasses ≈ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic is to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that will illustrate the different facets of the studies currently conducted in this domain.

Neuroendocrinology. --- Neuropharmacology. --- Endocrinology. --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Transduction pathways --- G protein-coupled receptors --- Neuroendocrinology --- Heptahelical receptors --- Neuropeptides --- Signaling mechanisms --- Biologically active peptides --- seven-transmembrane domain receptors

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The human genome encompasses ≈ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic is to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that will illustrate the different facets of the studies currently conducted in this domain.

Neuroendocrinology. --- Neuropharmacology. --- Endocrinology. --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Transduction pathways --- G protein-coupled receptors --- Neuroendocrinology --- Heptahelical receptors --- Neuropeptides --- Signaling mechanisms --- Biologically active peptides --- seven-transmembrane domain receptors --- Transduction pathways --- G protein-coupled receptors --- Neuroendocrinology --- Heptahelical receptors --- Neuropeptides --- Signaling mechanisms --- Biologically active peptides --- seven-transmembrane domain receptors