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Chemical modulators of protein misfolding and neurodegenerative disease
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ISBN: 012801959X 0128019441 1322639523 9780128019597 9780128019443 Year: 2015 Publisher: London, England : Academic Press,

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Abstract

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecula


Book
Molecular targets in protein misfolding and neurodegenerative disease
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ISBN: 0128103183 0128004991 0128001860 1322184011 9780128004999 9780128001868 9780128001868 1322639523 9781322639529 Year: 2015 Publisher: London : Academic Press,

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Aimed at ""drug discoverers"" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation,


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Chemical sciences in early drug discovery : medicinal chemistry 2.0
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ISBN: 008099928X 0080994202 9780080999289 9780080994208 Year: 2018 Publisher: Amsterdam, Netherlands : Elsevier,

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Molecular targets in protein misfolding and neurodegenerative disease
Author:
ISBN: 9780128004999 0128004991 0128001860 9780128001868 1322639523 9781322639529 0128103183 1322184011 Year: 2015 Publisher: London Academic Press

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Abstract

Aimed at ""drug discoverers"" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation,


Digital
Chemical modulators of protein misfolding and neurodegenerative disease
Author:
ISBN: 9780128019597 012801959X Year: 2015 Publisher: Amsterdam Boston :Elsevier/AP, Academic Press is an imprint of Elsevier

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Abstract

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents. Written to provide comprehensive coverage of neurodegenerative disease-modifying compounds Provides discipline-specific chapters that cover medicinal chemistry and clinical applications Provides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorder Coverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery.

Keywords

Neuropathology


Digital
Chemical sciences in early drug discovery : medicinal chemistry 2.0
Author:
ISBN: 9780080999289 008099928X Year: 2018 Publisher: Amsterdam Elsevier

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Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways in which medicinal chemistry is widening its reach to meet modern demands, and how modern technologies and approaches are facilitating this growth into new fields. Supported by examples throughout, the book is a practical resource for organic-medicinal chemists, biological chemists and pharmacologists involved in drug discovery.

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