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Descriptive organic chemistry --- Technology, Pharmaceutical --- Combinatorial Chemistry Techniques --- Gene Library --- Solid-phase synthesis --- Combinatorial chemistry --- 541.5 --- 615.015.2 --- #WSCH:LOSA --- Organic compounds --- Combinatorial organic synthesis --- Combinatorial synthesis (Organic chemistry) --- High-throughput organic synthesis --- High-throughput synthesis (Organic chemistry) --- Multiple parallel synthesis (Organic chemistry) --- Pharmaceutical chemistry --- Biochips --- Valencies. Bonds. Affinity --- Combined effects. Action of combination of drugs --- Synthesis --- Combinatorial chemistry. --- Solid-phase synthesis. --- 615.015.2 Combined effects. Action of combination of drugs --- 541.5 Valencies. Bonds. Affinity
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This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecula
Protein folding --- Molecular neurobiology --- Nervous system --- Biochemical Processes --- Investigative Techniques --- Biophysical Processes --- Neurodegenerative Diseases --- Drug Therapy --- Nervous System Diseases --- Biophysical Phenomena --- Chemical Processes --- Therapeutics --- Physical Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biochemical Phenomena --- Diseases --- Chemical Phenomena --- Physical Phenomena --- Phenomena and Processes --- Molecular Targeted Therapy --- Protein Folding --- Methods --- Tauopathies --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Neurology --- Degeneration --- Degeneration. --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration (Pathology) --- Degeneration and regeneration
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Aimed at ""drug discoverers"" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation,
Molecular neurobiology. --- Nervous system --- Diseases. --- Medical neurology --- Nerves --- Neurologic disorders --- Neurological disorders --- Neuropathology --- Neurology --- Molecular neurology --- Molecular biology --- Neurobiology --- Diseases --- Molecular aspects
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Aimed at ""drug discoverers"" - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation,
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This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents. Written to provide comprehensive coverage of neurodegenerative disease-modifying compounds Provides discipline-specific chapters that cover medicinal chemistry and clinical applications Provides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorder Coverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery.
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Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways in which medicinal chemistry is widening its reach to meet modern demands, and how modern technologies and approaches are facilitating this growth into new fields. Supported by examples throughout, the book is a practical resource for organic-medicinal chemists, biological chemists and pharmacologists involved in drug discovery.
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