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This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Proteins -- Physiological transport. --- Proteins --- Signal Transduction --- Metabolism --- Cell Membrane --- Protein Transport --- Cell Physiological Processes --- Metabolic Phenomena --- Biochemical Processes --- Biological Transport --- Cell Physiological Phenomena --- Cellular Structures --- Chemical Processes --- Phenomena and Processes --- Cells --- Biochemical Phenomena --- Chemical Phenomena --- Anatomy --- Animal Biochemistry --- Cytology --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Physiological transport --- Physiological transport. --- Life sciences. --- Medical microbiology. --- Biochemistry. --- Cell biology. --- Life Sciences. --- Biochemistry, general. --- Cell Biology. --- Biomedicine general. --- Medical Microbiology. --- Cell biology --- Cellular biology --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Biosciences --- Sciences, Life --- Science --- Composition

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Choose an application

• Reference Manager
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The SecretoryPathway The transport ofproteins and lipids from their site ofsynthesis at the endoplasmic reticu­ lum (ER) to the cellsurface ismediated by the secretory pathway and isan essential process in eukaryotic organisms. A great variety ofmolecules are extruded from cellsby the action ofthe secretory pathway, including extracellular matrix components that provide the foundation for constructing tissuesand organs. Moreover, this pathway playsa major role in the biogenesisof the plasma membraneand itsexpansion before celldivision. Therefore, withoutsecretion there would be no cells,tissuesor organs, and so it issafeto saythat we oweourvery existence to the secretory pathway. To understand the process ofsecretion we must learn about the organelles that compose the secretory pathway; the ER and Golgi apparatus, and the transport vesicles these or­ ganelles produce. The membrane ofthese organelles is primarily synthesized and assembled at the ER but with contributions from mitochondria (phosphatidylethanolamine) and the Golgi apparatus (sphingolipids). Newly synthesized proteins destined for secretion gain en­ try into the secretory pathway by translocation across the ER membrane. This translocation apparatus also integrates proteins into the membrane and establishes their topology with respect to the lipid bilayer (seeChapter 7). Many secretory proteins are covalently modified with oligosaccharides to produce glycoproteins, a biosynthetic process initiated in the ER and continued in the Golgi apparatus. Once proteins are properly folded and modified in the ER, they are allowed to leave and are ushered into COPlI-coated carrier vesiclesforming at specific exit sites (see Chapters 1 and 8).

Proteins --- Physiological transport.