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Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites for therapeutic application. The Special Issue contains 16 articles reporting relevant experimental results, and an overview of bioactive secondary metabolites, their biological effects, and new methodologies that improve and accelerate the process of obtained lead compounds with regard to new drug development. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this Special Issue.

antitumor --- triterpenoids --- seaweeds --- diterpenes --- Boswellia --- antioxidant activity --- antiplasmodial --- Maytenus chiapensis --- phenolic derivatives --- secondary metabolites --- medicinal applications --- Malus x domestica --- pectin --- cytotoxic activity --- xanthine oxidase --- phytochemistry --- antioxidant --- Scabiosa --- sugars --- sargaquinoic acid --- pentacyclic triterpenoids --- analysis --- antimicrobial and anticancer activity --- iridoids --- Tuscany --- GC-MS --- (-)-rabdosiin --- kratom --- plant defense --- cembranoids --- tingenone --- deoxypodophyllotoxin --- anticancer --- pristimerin --- inflammation --- boswellic acids --- plants --- anti-inflammatory --- legalization --- Mitragyna speciosa --- Ocimum sanctum --- cordycepin --- cytotoxic --- medicine --- Artemisia species --- antimicrobial activity --- lignans --- Artemisia vachanica --- Cordyceps militaris --- frankincense --- ancient varieties --- sargahydroquinoic acid --- Tajikistan --- antiSMASH --- ABTS --- polyphenols --- therapeutics --- infectious diseases --- antibacterial --- nutraceutics --- total phenolics --- LC-MS/MS --- innate immunity --- HPLC-PAD --- sarganaphthoquinoic acid --- biosynthetic gene clusters --- DPPH --- EGCG --- cneorubenoids --- PPAR-? --- bowel diseases --- amentoflavone --- molecular docking --- sargachromenoic acid --- cannabinoids --- flavonoids --- essential oils --- TCM --- HPLC-PDA --- ascorbic acid --- antioxidants --- Lamiaceae --- nanoemulsion --- malaria --- therapeutic uses --- quinonemethide triterpenoids --- artemisinin --- natural products --- biological activities --- FRAP --- toxicology --- defensins --- Celastraceae --- cannabis --- vector control --- Juniperus --- analytical determination

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Natural compounds, from terrestrial and marine sources, are the result of an evolutionary process which originated in compounds with great structural diversity, multiple biological activities and miscellaneous applications. A large and very active research field is dedicated to identifying biosynthesized compounds; to improve/develop new methodologies to produce/reuse natural compounds; to assess their potential; and to understand their mechanism of action. This Special Issue brings together excellent original and review works, focused on the most recent advances related to the secondary metabolites’ composition of natural sources, and the proposal of new applications for their constituents, such as therapeutic agents, and pesticides or food ingredients.

Research & information: general --- Biology, life sciences --- heterologous expression --- Streptomyces --- secondary metabolite --- Garcinia xanthochymus --- growth inhibitory compounds --- allelopathy --- vanillic acid --- methyl phloretate --- allelopathic activity --- growth inhibitor --- phenolic compounds --- bioherbicide --- sustainable agriculture --- pulsed electric fields --- green extraction --- microalgae --- antioxidants --- pigments --- thymoquinone --- UHRF1 --- ubiquitination --- HAUSP --- tumor suppressor genes --- aaptoline B --- pyrroloquinoline --- Ag(I)-catalyzed cycloisomerization --- dopaminergic neuroprotection --- Parkinson's disease --- bioactive compounds --- cardiovascular --- nanodelivery --- bioavailability --- Ailanthus altissima --- biological properties --- analytical techniques --- potential applications --- propolis contamination --- propolis cytotoxicity --- antimicrobial activity --- antiprotozoal activity --- artepelin C --- formononetin --- pinocembrin --- quercetin --- kaempferol --- propolis extract --- Asparagopsis armata --- Rhodophyta --- GC-MS --- UHPLC-MS --- dibrominated compounds --- 1,4-dibromobuten-1-ol --- palmitic acid --- brominated phenolics --- red seaweed --- invasive seaweed --- invasive species --- flowers --- antioxidant --- microbial activity --- bioactivity --- enzyme inhibitory potential --- acetylcholinesterase --- lipase --- α-glucosidase --- heterologous expression --- Streptomyces --- secondary metabolite --- Garcinia xanthochymus --- growth inhibitory compounds --- allelopathy --- vanillic acid --- methyl phloretate --- allelopathic activity --- growth inhibitor --- phenolic compounds --- bioherbicide --- sustainable agriculture --- pulsed electric fields --- green extraction --- microalgae --- antioxidants --- pigments --- thymoquinone --- UHRF1 --- ubiquitination --- HAUSP --- tumor suppressor genes --- aaptoline B --- pyrroloquinoline --- Ag(I)-catalyzed cycloisomerization --- dopaminergic neuroprotection --- Parkinson's disease --- bioactive compounds --- cardiovascular --- nanodelivery --- bioavailability --- Ailanthus altissima --- biological properties --- analytical techniques --- potential applications --- propolis contamination --- propolis cytotoxicity --- antimicrobial activity --- antiprotozoal activity --- artepelin C --- formononetin --- pinocembrin --- quercetin --- kaempferol --- propolis extract --- Asparagopsis armata --- Rhodophyta --- GC-MS --- UHPLC-MS --- dibrominated compounds --- 1,4-dibromobuten-1-ol --- palmitic acid --- brominated phenolics --- red seaweed --- invasive seaweed --- invasive species --- flowers --- antioxidant --- microbial activity --- bioactivity --- enzyme inhibitory potential --- acetylcholinesterase --- lipase --- α-glucosidase

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Nature represents an amazing source of inspiration, since it produces a great diversity of natural compounds selected by evolution, which exhibit multiple biological activities and applications. A large and very active research field is dedicated to identifying biosynthesized compounds, to improve/develop new methodologies, to produce/reuse natural compounds, and to assess their potential for pharmaceutical, cosmetic and food industries, among others, and additionally, to understand their mechanism of action. This book is dedicated to presenting the most recent results on the development of natural compounds’ applications. Ten original research works, organized by applications, and two reviews are included. Each of them contributes to the knowledge advance, insofar as they present new applications for known products, new methodologies to obtain new products, or the evaluation of a given application, with the applications related to health promotion being the most frequently considered. These works are significant contributions and reinforce the dynamic field of natural products’ applications.

amino acid metabolism --- carvacrol --- metabolomics data --- oxidative stress --- Penicillium digitatum --- Prangos pabularia Lindl. --- volatile oil --- PTP-1B --- osthole --- 5-pentylcyclohexa-1,3-diene --- antidiabetic activity --- chalcones --- aldol condensation --- biological activity --- flavanones --- cytotoxic --- antioxidant --- anticholinesterase --- Maytenus --- celastroloids --- semisynthesis --- antibacterial activity --- structure–activity relationship --- rosemary --- rosmarinic acid --- anticancer --- antidiabetic --- cardioprotective --- Helianthus annuus --- Helianthus strumosus --- Aspergillus niger --- Candida albicans --- Cryptococcus neoformans --- α-pinene --- oleracone --- flavonoid --- anti-aging --- longevity --- Portulaca oleracea L. --- Caenorhabditis elegans --- total synthesis --- pimenta d’água --- Candida --- fungistatic effect --- inhibition of dimorphism --- GC/MS --- colorectal cancer --- Salviae miltiorrhizae radix --- apoptosis --- honey --- propolis --- phenolic compounds --- wound-healing activity --- NHDF cells --- Asteraceae --- sesquiterpene lactones --- alantolactone --- arglabin --- parthenolide --- thapsigargin --- in vivo study --- anti-inflammatory --- almond --- byproducts --- chlorogenic acid --- design of experiment --- phenolic acids --- ultrasound-assisted extraction --- natural compounds --- therapeutic applications --- essential oils --- antimicrobial --- antitumor --- SAR