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Medical technology. --- Clinical medicine. --- Medical innovations. --- Innovations, Medical --- Medicine --- Medical technology --- Technological innovations --- Health care technology --- Health technology --- Technology --- Medicine, Clinical --- Innovations --- Tecnologia mèdica --- Medicina clínica

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Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Cardiology. --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Heart --- Internal medicine --- Diseases --- Oxigen actiu --- Ús terapèutic --- Farmacologia --- Pharmacology. --- Clinical biochemistry. --- Neuroscience. --- Medical Biochemistry. --- Medicina --- Biofarmàcia --- Biotransformació (Metabolisme) --- Dermofarmacologia --- Desenvolupament de medicaments --- Estabilitat dels medicaments --- Farmacocinètica --- Farmacogenètica --- Farmacologia cardiovascular --- Farmacologia clínica --- Farmacologia dental --- Farmacologia geriàtrica --- Farmacologia molecular --- Farmacologia obstètrica --- Farmacologia ocular --- Farmacologia pediàtrica --- Farmacologia respiratòria --- Farmacologia renal --- Farmacologia veterinària --- Fotofarmacologia --- Immunofarmacologia --- Isòtops radioactius en farmacologia --- Neurofarmacologia --- Psicofarmacologia --- Química farmacèutica --- Radiofàrmacs --- Resistència als medicaments --- Toxicologia --- Medicaments --- Quimioteràpia --- Aplicacions mèdiques --- Aplicacions terapèutiques --- Ús en medecina --- Medicina alternativa --- Terapèutica --- Anions superòxid --- Oxigen reactiu --- Radicals d'oxigen --- Oxigen --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.

Biochemistry. --- Cyclic adenylic acid. --- Cyclic GMP. --- Cyclic guanylic acid. --- Medicine. --- Protein kinase --Metabolism --Collected works. --- Protein kinases. --- Nucleotides, Cyclic --- Guanine Nucleotides --- Purine Nucleotides --- Ribonucleotides --- Nucleotides --- Nucleic Acids, Nucleotides, and Nucleosides --- Purines --- Chemicals and Drugs --- Heterocyclic Compounds, 2-Ring --- Heterocyclic Compounds --- Cyclic GMP --- Health & Biological Sciences --- Human Anatomy & Physiology --- Pharmacy, Therapeutics, & Pharmacology --- Animal Biochemistry --- Cyclic nucleotides. --- cGMP (Biochemical) --- Cyclic guanosine monophosphate --- Guanosine cyclic monophosphate --- Guanylic acid, Cyclic --- Life sciences. --- Human physiology. --- Molecular biology. --- Pharmacology. --- Medical biochemistry. --- Life Sciences. --- Biochemistry, general. --- Pharmacology/Toxicology. --- Medical Biochemistry. --- Human Physiology. --- Molecular Medicine. --- Cyclic nucleotides --- Toxicology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Physiology --- Human body --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Toxicology --- Composition --- Health Workforce --- Pharmacologies --- Pharmaceutical Preparations --- pharmacology --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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History of human medicine --- Human biochemistry --- Pathological biochemistry --- Pathology of the circulatory system --- Neuropathology --- neurologie --- farmacologie --- biochemie --- cardiologie