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Evolutionary genomics is a new discipline that bridges the fields of molecular evolution, bioinformatics and genomics in order to provide a unique perspective on the history of life.  This easy-to-follow textbook is the first of its kind to explain the fundamentals of evolutionary genomics. The comprehensive coverage includes concise descriptions of a variety of genome organizations, a thorough discussion of the methods used, and a detailed review of genome sequence processing procedures. The opening chapters also provide the necessary basics for readers unfamiliar with evolutionary studies.  Topics and features: Introduces the basics of molecular biology, DNA replication, mutation, phylogeny, neutral evolution, and natural selection Presents a brief evolutionary history of life from the primordial seas to the emergence of modern humans Describes the genomes of prokaryotes, eukaryotes, vertebrates, and humans Reviews methods for genome sequencing, phenotype data collection, homology searches and analysis, and phylogenetic tree and network building Discusses databases of genome sequences and related information, evolutionary distances, and population genomics Provides supplementary material at the website http://www.saitou-naruya-laboratory.org/Evolutionary_Genomics/ This essential text/reference provides an easy-to-read introduction to the field for undergraduate and graduate students, post-doctoral fellows, and established researchers from both computer science and the biological sciences. Dr. Naruya Saitou is a Professor in the Division of Population Genetics at the National Institute of Genetics, and a Professor in the Department of Genetics at the Graduate University for Advanced Studies, Mishima, Japan. He is also a Professor in the Department of Biological Sciences at the University of Tokyo, Japan.

Evolutionary genetics --- Genomics --- Gene mapping --- Evolution (Biology) --- Biology --- Health & Biological Sciences --- Biology - General --- Statistical methods --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Chromosome mapping --- Genetic mapping --- Genome mapping --- Linkage mapping (Genetics) --- Mapping, Gene --- Genome research --- Genomes --- Genetic evolution --- Evolution --- Research --- Computer science. --- Bioinformatics. --- Systems biology. --- Microbial genetics. --- Microbial genomics. --- Plant genetics. --- Animal genetics. --- Computer Science. --- Computational Biology/Bioinformatics. --- Systems Biology. --- Microbial Genetics and Genomics. --- Plant Genetics & Genomics. --- Animal Genetics and Genomics. --- Biological models. --- Plant Genetics and Genomics. --- Models, Biological --- Genetics --- Plants --- Microbial genetics --- Microorganisms --- Microbiology --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Data processing --- Genomics. --- Gene mapping. --- Statistical methods. --- Bioinformatics --- Biological systems --- Molecular biology

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This authoritative textbook/reference presents a comprehensive introduction to the field of evolutionary genomics. The opening chapters describe the fundamental concepts in molecular biology and genome evolution for readers without any prior background in this area. This is followed by a detailed examination of genome evolution in various different groups of organisms. The text then concludes with a review of practical methods essential to researchers in the field. This updated and revised new edition also features historical perspectives on contributions to evolutionary genomics from related fields such as molecular evolution, genetics, and numerical taxonomy. Topics and features: Introduces the basics of molecular biology, covering protein structure and diversity, as well as DNA replication, transcription, and translation Examines the phylogenetic relationships of DNA sequences, and the processes of mutation, neutral evolution, and natural selection Presents a brief evolutionary history of life, surveying the key features of the genomes of prokaryotes, eukaryotes, viruses and phages, vertebrates, and humans Reviews the various biological “omic” databases, and discusses the analysis of homologous nucleotide and amino acid sequences Provides an overview of the experimental sequencing of genomes and transcriptomes, and the construction of phylogenetic trees Describes methods for estimating of evolutionary distances, and performing studies of population genetics Supplies additional supporting material at an associated website Serving as an indispensable textbook for graduate and advanced undergraduate courses on evolutionary genomics, this accessible overview will also prove invaluable to researchers from both computer science and the biological sciences seeking a primer on the field. Dr. Naruya Saitou is a Professor in the Division of Population Genetics at the National Institute of Genetics, and a Professor in the Department of Genetics at the Graduate University for Advanced Studies, Mishima, Japan. He is also a Professor in the Department of Biological Sciences at the University of Tokyo, Japan.

Bioinformatics. --- Biological models. --- Microbial genetics. --- Microbial genomics. --- Plant genetics. --- Animal genetics. --- Computational Biology/Bioinformatics. --- Systems Biology. --- Microbial Genetics and Genomics. --- Plant Genetics and Genomics. --- Animal Genetics and Genomics. --- Genetics --- Plants --- Genomics --- Microbial genetics --- Microorganisms --- Microbiology --- Models, Biological --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Data processing --- Systems biology. --- Bioinformatics --- Biological systems --- Molecular biology

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Evolutionary genomics is a new discipline that bridges the fields of molecular evolution, bioinformatics and genomics in order to provide a unique perspective on the history of life.  This easy-to-follow textbook is the first of its kind to explain the fundamentals of evolutionary genomics. The comprehensive coverage includes concise descriptions of a variety of genome organizations, a thorough discussion of the methods used, and a detailed review of genome sequence processing procedures. The opening chapters also provide the necessary basics for readers unfamiliar with evolutionary studies.  Topics and features: Introduces the basics of molecular biology, DNA replication, mutation, phylogeny, neutral evolution, and natural selection Presents a brief evolutionary history of life from the primordial seas to the emergence of modern humans Describes the genomes of prokaryotes, eukaryotes, vertebrates, and humans Reviews methods for genome sequencing, phenotype data collection, homology searches and analysis, and phylogenetic tree and network building Discusses databases of genome sequences and related information, evolutionary distances, and population genomics Provides supplementary material at the website http://www.saitou-naruya-laboratory.org/Evolutionary_Genomics/ This essential text/reference provides an easy-to-read introduction to the field for undergraduate and graduate students, post-doctoral fellows, and established researchers from both computer science and the biological sciences. Dr. Naruya Saitou is a Professor in the Division of Population Genetics at the National Institute of Genetics, and a Professor in the Department of Genetics at the Graduate University for Advanced Studies, Mishima, Japan. He is also a Professor in the Department of Biological Sciences at the University of Tokyo, Japan.

Biomathematics. Biometry. Biostatistics --- Genetics --- Molecular biology --- Biology --- Plant physiology. Plant biophysics --- Botany --- Animal genetics. Animal evolution --- Agriculture. Animal husbandry. Hunting. Fishery --- Biotechnology --- Computer science --- Programming --- systematische plantkunde --- genomen (geneeskunde) --- medische genetica --- bio-informatica --- genomics --- biologie --- bevolking --- computers --- genetica --- biotechnologie --- biometrie --- computerkunde --- moleculaire biologie

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This book reviews the human genome from an evolutionary perspective. No such book has ever been published before, although there are many books on human genomes. There are two parts in this book: Overview of the Human Genome (Part I) and The Human Genome Viewed through Genes (Part II). In Part I, after a brief review of human evolution and the human genome (by Naruya Saitou), chapters on rubbish or junk DNA (by Dan Graur), GC content heterogeneity (by Satoshi Oota), protein coding and RNA coding genes (by Tadashi Imanishi), duplicated genes (by Takashi Kitano), recombinations (by Montanucci and Bertranpetit), and copy number variations including microsatellites (by Naoko Takezaki) are discussed. Readers can obtain various new insights on the human genome from this part. In Part II, genes in X and Y chromosomes (by Yoko Satta and others), HLA genes (by Timothy A. Jinam), opsin genes (by Shoji Kawamura and Amanda D. Melin), genes related to phenotypic variations (by Ryosuke Kimura), transcription factors (by Mahoko Takahashi and So Nakagawa), diabetes-related genes (by Ituro Inoue), disease genes in general (by Ituro Inoue and Hirofumi Nakaoka), and microbial genomes (by Chaochun Wei) are discussed. The human genome sequences were determined in 2004, and after more than 10 years we are now beginning to understand the human genome from an evolutionary point of view. This book furnishes readers with a good summary of current research in the field.

Ethnology. Cultural anthropology --- Evolution. Phylogeny --- Human genetics --- medische genetica --- genetica --- Europees recht --- evolutieleer --- antropologie

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Ethnology. Cultural anthropology --- Evolution. Phylogeny --- Human genetics --- medische genetica --- Europees recht --- evolutieleer --- antropologie