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Gene transfer : delivery and expression of DNA and RNA
Authors: ---
ISBN: 9780879697655 9780879697648 0879697652 0879697644 Year: 2006 Publisher: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press,

MicroRNA methods
Authors: ---
ISBN: 9780123739179 0123739179 Year: 2007 Volume: 427 Publisher: Amsterdam : Academic press,

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RNA interference.
Authors: ---
ISSN: 00766879 ISBN: 0121827976 9786610633395 1280633395 0080455395 9780121827977 Year: 2005 Volume: 392 Publisher: Amsterdam Elsevier

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Abstract

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.RNA Interference will cover RNAi in non-vertebrates (plants, C. elegans, drosophila, and S. pombe), and Mammalian systems (human and non-human cells). This volume discusses e

MicroRNA methods
Authors: ---
ISBN: 0123739179 9786611038281 1281038288 0080551394 Year: 2007 Publisher: Amsterdam ; London : Elsevier,

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Abstract

MicroRNAs (miRNA) are tiny bits of genetic material that were unknown nearly 10 years ago but now represent an exciting field of study in biology. Upon their discovery, researchers revealed for the first time a new mechanism by which microRNA can stop the function of messenger RNA (mRNA) by literally cutting it in half, interfering with the normal function of specific messenger RNAs in gene expression. This ""expression"" of genes that code for essential proteins is essentially what controls whether a cell turns into a liver, lung, or brain cell, for example. Understanding what activat


Book
RNA therapeutics : the evolving landscape of RNA therapeutics
Authors: --- ---
ISBN: 012821595X 0128217391 9780128217399 9780128215951 Year: 2022 Publisher: London, UK : Elsevier,

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Provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development.

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