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Genetic transformation --- Genetic engineering --- Gene expression --- Genetic vectors. --- Viruses --- Transfert de gènes --- Génie génétique --- Expression génique --- Vecteurs de clonage --- Virus --- Gene Expression Regulation --- Gene Transfer Techniques --- Genetic Vectors --- Genetic vectors --- genetics --- Genetics
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Petits ARN interférents --- MicroRNAs --- Small interfering RNA --- Small interfering RNA.
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The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.RNA Interference will cover RNAi in non-vertebrates (plants, C. elegans, drosophila, and S. pombe), and Mammalian systems (human and non-human cells). This volume discusses e
RNA Interference. --- Small interfering RNA. --- RNA Interference --- RNA, Small Interfering --- Gene Silencing --- Epigenesis, Genetic --- RNA, Antisense --- RNA, Small Untranslated --- RNA --- Antisense Elements (Genetics) --- RNA, Untranslated --- Gene Expression Regulation --- Nucleic Acids, Nucleotides, and Nucleosides --- Genetic Processes --- Nucleic Acids --- Genetic Phenomena --- Chemicals and Drugs --- Phenomena and Processes --- RNA editing --- Gene silencing --- Small interfering RNA --- piRNA (Piwi-interacting RNA) --- Piwi-interacting RNA --- Piwi protein-interacting RNA --- rasiRNA (Repeat-associated small interfering RNA) --- Repeat-associated siRNA --- Repeat-associated small interfering RNA --- Scan RNA --- scnRNA (Small scan RNA) --- Short hairpin RNA --- Short interfering RNA --- shRNA (Short hairpin RNA) --- siRNA (Small interfering RNA) --- Small hairpin RNA --- Small scan RNA --- tasiRNA (Trans-acting small interfering RNA) --- Trans-acting siRNA --- Trans-acting small interfering RNA --- Gene inactivation --- Inactivation, Gene --- Silencing, Gene --- Editing, RNA --- Messenger RNA editing --- mRNA editing --- Ribonucleic acid --- Ribose nucleic acid --- Antisense RNA --- Genetic regulation --- Nucleic acids --- Ribose
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MicroRNAs (miRNA) are tiny bits of genetic material that were unknown nearly 10 years ago but now represent an exciting field of study in biology. Upon their discovery, researchers revealed for the first time a new mechanism by which microRNA can stop the function of messenger RNA (mRNA) by literally cutting it in half, interfering with the normal function of specific messenger RNAs in gene expression. This ""expression"" of genes that code for essential proteins is essentially what controls whether a cell turns into a liver, lung, or brain cell, for example. Understanding what activat
MicroRNAs. --- RNA, Small Interfering. --- Small interfering RNA. --- MicroRNAs --- RNA, Messenger --- Sequence Analysis, RNA --- RNA --- RNA, Antisense --- Sequence Analysis --- RNA, Small Untranslated --- RNA, Untranslated --- Nucleic Acids --- Genetic Techniques --- Antisense Elements (Genetics) --- Investigative Techniques --- Nucleic Acids, Nucleotides, and Nucleosides --- Chemicals and Drugs --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physiology. --- Animal physiology --- Animals --- piRNA (Piwi-interacting RNA) --- Piwi-interacting RNA --- Piwi protein-interacting RNA --- rasiRNA (Repeat-associated small interfering RNA) --- Repeat-associated siRNA --- Repeat-associated small interfering RNA --- Scan RNA --- scnRNA (Small scan RNA) --- Short hairpin RNA --- Short interfering RNA --- shRNA (Short hairpin RNA) --- siRNA (Small interfering RNA) --- Small hairpin RNA --- Small scan RNA --- tasiRNA (Trans-acting small interfering RNA) --- Trans-acting siRNA --- Trans-acting small interfering RNA --- Physiology --- Biology --- Anatomy --- Antisense RNA
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Provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development.
RNA --- Ribonucleic acid --- Ribose nucleic acid --- Nucleic acids --- Ribose --- Therapeutic use. --- Therapeutic use --- Testing. --- therapeutic use
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