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In Gene Therapy Protocols, leading researchers describe in detail all the essential molecular methods for developing gene transfer systems, along with the methods for introducing genes into specific tissue types either in vivo or ex vivo. These easily reproducible methods range from those for specific viral and nonviral delivery systems, to those concerned with gene delivery to particular tissues. Methods for applying specific therapeutic systems, such as ribozymes and tumor suppressor genes for the treatment of AIDS and cancer, are also included in this authoritative collection. Gene Therapy Protocols is the first major collection of the methods needed for successful gene delivery and subsequent in vivo gene expression, techniques at the center of the many and significant recent advances in the treatment of both genetic and acquired diseases. It will surely become today's indispensable standard reference source for all scientists working to realize the promises of gene therapy.
Human genetics. --- Human Genetics. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Gene therapy --- Genetic Therapy --- Gene Transfer. --- Methodology. --- methods.
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In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.
Autoimmune diseases -- Gene therapy. --- Autoimmune diseases -- Therapy. --- Gene therapy -- Methods. --- Inflammation -- Gene therapy. --- Inflammation -- Therapy. --- Autoimmune diseases --- Inflammation --- Investigative Techniques --- Genetic Engineering --- Biological Therapy --- Immune System Diseases --- Pathologic Processes --- Diseases --- Genetic Techniques --- Pathological Conditions, Signs and Symptoms --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Gene Therapy --- Methods --- Autoimmune Diseases --- Medicine --- Health & Biological Sciences --- Clinical Immunology --- Pathology --- Gene therapy --- Inflammation. --- Gene therapy. --- Autoimmunologic diseases --- Therapy, Gene --- Inflammatory process --- Medicine. --- Immunology. --- Molecular biology. --- Pharmacology. --- Rheumatology. --- Biomedicine. --- Gene Therapy. --- Pharmacology/Toxicology. --- Molecular Medicine. --- Genetic engineering --- Autoimmunity --- Immunologic diseases --- Anti-inflammatory agents --- Toxicology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Internal medicine --- Connective tissues --- Joints --- Immunobiology --- Serology --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect
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In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.
Molecular biology --- History of human medicine --- Immunology. Immunopathology --- Pharmacology. Therapy --- Pathology of the organs of movement --- immunologie --- farmacologie --- toxicologie --- reumatologie --- gentherapie --- moleculaire biologie
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Anti-Inflammatory Agents. --- Autoimmune Diseases --- Autoimmune diseases --- Gene Therapy. --- Inflammation --- Transplantation Immunology. --- Therapy. --- Gene therapy. --- Gene therapy.
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In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not only from the quantitative point of view, but also for currently unknown and unexpected secondary effects of the vector or the transgene. Some of these approaches have already been tested in the clinic, but much more needs to be done to understand the human conditions treated and the n- ural history of their pathology. We are indebted to the secretarial assistance of Ms. Lin Wells (Bone and Joint Research Unit, London, UK) and the help of Hans Detlef Klüber for his help in getting this book published. We hope this book will be of interest to c- nicians and scientists and inspiring to students of the subject who will use their own ingenuity and knowledge to further forward this discipline into clinical use.
Molecular biology --- History of human medicine --- Immunology. Immunopathology --- Pharmacology. Therapy --- Pathology of the organs of movement --- immunologie --- farmacologie --- toxicologie --- reumatologie --- gentherapie --- moleculaire biologie
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