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Technological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors.  This book provides an overview of the design considerations and technical approaches used to generate these important models of human cancer.   These models are designed to recapitulate molecular aberrations in target organs known to drive human cancers.  State-of-the-art methods to analyze genome and transcriptome alterations in these models and particular relationships to human cancers are presented.  Mouse-human comparisons of tumor pathologies are exemplified.  Criteria for selecting relevant models for preclinical studies that might be translatable to the treatment of human cancers are discussed.  The topics presented in this book will be invaluable to both newcomers to the field as well as established investigators who use genetically-engineered mouse models to study the development, progression and treatment of cancer.

Cancer -- Animal models. --- Mice -- Genetic engineering. --- Mice as laboratory animals. --- Transgenic mice. --- Mice --- Transgenic mice --- Mice as laboratory animals --- Cancer --- Organism Forms --- Models, Biological --- Animal Population Groups --- Models, Animal --- Animal Diseases --- Animals, Genetically Modified --- Diseases --- Investigative Techniques --- Models, Theoretical --- Murinae --- Organisms --- Animals --- Eukaryota --- Muridae --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Rodentia --- Mammals --- Vertebrates --- Chordata --- Disease Models, Animal --- Mice, Transgenic --- Animals, Laboratory --- Organisms, Genetically Modified --- Medicine --- Biology --- Health & Biological Sciences --- Genetics --- Oncology --- Genetic engineering --- Animal models --- Animal models. --- Research. --- Cancer research --- Medicine. --- Cancer research. --- Human genetics. --- Laboratory medicine. --- Medical microbiology. --- Parasitology. --- Biochemistry. --- Biomedicine. --- Cancer Research. --- Human Genetics. --- Laboratory Medicine. --- Medical Microbiology. --- Animal Biochemistry. --- Transgenic animals --- Oncology. --- Medical laboratories. --- Microbiology. --- Medical parasitology. --- Human beings --- Human parasitology --- Medical sciences --- Parasitology --- Parasitic diseases --- Microbial biology --- Microorganisms --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Heredity, Human --- Human biology --- Physical anthropology --- Tumors --- Biological chemistry --- Chemical composition of organisms --- Physiological chemistry --- Chemistry --- Parasites --- Composition --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology

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This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Oncology. Neoplasms --- Human genetics --- medische genetica --- genetica --- oncologie