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Rhim and Kremer’s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells. Chapters cover all recently developed novel human cell models. In addition, the rapidly growing fields of knowledge regarding not only stem cells in cancer progression, but also the role of the microenvironments in human carcinogenesis are discussed. A wealth of topics is presented including: ·         Derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems ·         Oncogenes ·         Tumor suppressor genes ·         Viral transformation ·         In vitro model systems for viral, chemical and radiation carcinogenesis ·         Cell aging ·         The multistep nature of human carcinogenesis ·         The role of stem cells and the microenvironment in tumorigenesis ·         The genes involved in multistep carcinogenesis Unique in both scope and focus – devoted solely to human cell transformation systems – Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields. Essential reading for everyone who needs to be kept up-to-date in this fast-paced area!   Features Ø  Multistep models Ø  Breast cancer/Stem cells Ø  Prostate cancer/Stem cells Ø  Multistep / Genes.

Cell transformation -- Congresses. --- Cell Transformation, Neoplastic. --- Cellular Microenvironment. --- Stem Cells. --- Stem cells -- Congresses. --- Cell transformation --- Human cell culture --- Publication Formats --- Cells --- Neoplastic Processes --- Publication Characteristics --- Anatomy --- Pathologic Processes --- Neoplasms --- Pathological Conditions, Signs and Symptoms --- Diseases --- Congresses --- Cells, Cultured --- Stem Cells --- Cell Transformation, Neoplastic --- Biology --- Health & Biological Sciences --- Cytology --- Cell transformation. --- Human cell culture. --- Culture alteration (Cytology) --- Transformation of cells --- Life sciences. --- Cell biology. --- Stem cells. --- Life Sciences. --- Cell Biology. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cell biology --- Cellular biology --- Cytologists --- Biosciences --- Sciences, Life --- Science --- Cell culture --- Tissue culture --- Cytology.

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This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.

Cell biology. --- Cancer research. --- Oncology  . --- Cell Biology. --- Cancer Research. --- Oncology. --- Tumors --- Cancer research --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cancer cells --- Growth. --- Cancer cell growth

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