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Sepsis is a very important public health problem. It is widely acknowledged that the severe inflammatory response syndrome/severe sepsis paradigm fails to stratify sepsis patients adequately. This book reviews in detail how sepsis should be managed on the basis of a novel approach to staging. The PIRO (predisposing factors, infection, response, organ dysfunction) model was first proposed at the start of the decade on a theoretical basis and has now been translated into a practical approach for use at the bedside. It is loosely based on the TNM staging system for cancers, with points being allocated to each of the four aforementioned key characteristics of the septic process. The proposed PIRO framework facilitates evaluation of factors that are important in the pathogenesis of severe sepsis and in the development of treatment strategies. This book clearly explains the advantages of the PIRO approach in different settings and will be of value to all practitioners concerned with the management of sepsis.

Septicemia --Treatment. --- Septicemia. --- Septicemia --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Infection --- Systemic Inflammatory Response Syndrome --- Information Science --- Bacterial Infections and Mycoses --- Inflammation --- Pathologic Processes --- Diseases --- Pathological Conditions, Signs and Symptoms --- Diagnosis --- Classification --- Sepsis --- Cross Infection --- Medicine --- Health & Biological Sciences --- Emergency Medicine --- Infectious Diseases --- Treatment --- Opportunistic infections. --- Blood poisoning --- Poisoning, Blood --- Septicaemia --- Medicine. --- Anesthesiology. --- Critical care medicine. --- Internal medicine. --- Infectious diseases. --- Respiratory organs --- Medicine & Public Health. --- Intensive / Critical Care Medicine. --- Infectious Diseases. --- Pneumology/Respiratory System. --- Internal Medicine. --- Diseases. --- Blood --- Communicable diseases --- Emerging infectious diseases. --- Pneumology. --- Medicine, Internal --- Anaesthesiology --- Surgery --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Intensive care --- Intensive medicine --- Emergency medicine --- Intensive care units --- Respiratory organs—Diseases.

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Infectious diseases. Communicable diseases --- Orthopaedics. Traumatology. Plastic surgery --- Human medicine --- geneeskunde --- spoedgevallen --- intensieve zorgen --- besmettelijke ziekten

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This book is unique in approaching multiple organ dysfunction syndrome (MODS) from the perspective of its pathophysiological mechanism, and addressing aspects that are overlooked in most of the available literature. Eminent experts in the field from Europe and beyond offer new insights into risk stratification, severity assessment, and management of critically ill patients with sepsis. The principal focus is on recently developed concepts in infection management and in antibiotic use, bearing in mind that in these patients the pharmacokinetics of antibiotics are altered, affecting renal clearance and requiring dosage adjustments. The significance of the PIRO (predisposing factors, infection, response, organ dysfunction) model in the development of effective treatment strategies is emphasized. This book will be of interest and value to all who are involved in the treatment of, or research into, sepsis and MODS.

Multiple organ failure. --- Septicemia. --- Septicemia --- Multiple organ failure --- Shock --- Infection --- Systemic Inflammatory Response Syndrome --- Investigative Techniques --- Communicable Disease Control --- Public Health Practice --- Pathologic Processes --- Inflammation --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Bacterial Infections and Mycoses --- Diseases --- Pathological Conditions, Signs and Symptoms --- Public Health --- Environment and Public Health --- Health Care --- Infection Control --- Sepsis --- Methods --- Multiple Organ Failure --- Medicine --- Health & Biological Sciences --- Emergency Medicine --- Infectious Diseases --- Treatment --- Septic shock --- Treatment. --- Bacteremic shock --- Bacterial shock --- Endotoxic shock --- Endotoxin shock --- Blood poisoning --- Poisoning, Blood --- Septicaemia --- Medicine. --- Anesthesiology. --- Critical care medicine. --- Internal medicine. --- Infectious diseases. --- Respiratory organs --- Medicine & Public Health. --- Intensive / Critical Care Medicine. --- Infectious Diseases. --- Pneumology/Respiratory System. --- Internal Medicine. --- Diseases. --- Blood --- Communicable diseases --- Emerging infectious diseases. --- Pneumology. --- Medicine, Internal --- Anaesthesiology --- Surgery --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Intensive care --- Intensive medicine --- Emergency medicine --- Intensive care units --- Respiratory organs—Diseases.

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Physiology of the respiratory system --- Anesthesiology --- Infectious diseases. Communicable diseases --- Orthopaedics. Traumatology. Plastic surgery --- Human medicine --- farmacologie --- geneeskunde --- anesthesie --- spoedgevallen --- intensieve zorgen --- pneumologie --- besmettelijke ziekten

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Sepsis is an important public health problem around the world. Severe sepsis carries significant morbidity, mortality and high costs. The incidence of sepsis is increasing because of the aging population, the growing number of immunocompromised hosts, the increasing use of invasive procedures, and, to a lesser extent, antibiotic resistance among pathogens. Despite recent advances in the pathogenesis, diagnosis, and therapeutic approaches the mortality rate associated with this condition remains high. Therefore, the goal of Sepsis: New Strategies is to review novel targets to be considered in patients with severe sepsis and to assess new developments for patients with sepsis originating in the respiratory tract.

Infectious diseases. Communicable diseases --- Orthopaedics. Traumatology. Plastic surgery --- Human medicine --- geneeskunde --- spoedgevallen --- intensieve zorgen --- besmettelijke ziekten