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"The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notch signalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate and assist those in related disciplines to enter this exciting field of research"--Provided by publisher.

Cellular signal transduction. --- Neoplasms. --- Receptors, Notch. --- Receptors. --- Biochemical Processes --- Receptors, Cell Surface --- Diseases --- Transcription Factors --- Cell Physiological Processes --- Embryonic and Fetal Development --- Metabolic Phenomena --- Biological Science Disciplines --- Biochemical Phenomena --- Morphogenesis --- Natural Science Disciplines --- Membrane Proteins --- Phenomena and Processes --- Reproduction --- Cell Physiological Phenomena --- Chemical Processes --- Proteins --- Growth and Development --- Reproductive Physiological Processes --- Chemical Phenomena --- Disciplines and Occupations --- Amino Acids, Peptides, and Proteins --- Physiological Processes --- Reproductive Physiological Phenomena --- Chemicals and Drugs --- Physiological Phenomena --- Reproductive and Urinary Physiological Phenomena --- Embryonic Development --- Metabolism --- Physiology --- Neoplasms --- Receptors, Notch --- Signal Transduction --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Oncology --- Animal Biochemistry --- Notch proteins. --- Embryology. --- Cancer. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Animal embryology --- Animals --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Embryology --- Development --- Medicine. --- Cancer research. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Developmental biology --- Morphology (Animals) --- Embryos --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Membrane proteins --- Notch genes --- Oncology. --- Cytology.

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This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.

Cancer research. --- Cell biology. --- Embryology. --- Cancer Research. --- Cell Biology. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Animal embryology --- Animals --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Developmental biology --- Morphology (Animals) --- Embryos --- Reproduction --- Cell biology --- Cellular biology --- Biology --- Cells --- Cancer research --- Embryology --- Development --- Cancer --- Cytology. --- Research.

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Histology. Cytology --- Oncology. Neoplasms --- oncologie --- cytologie --- histologie

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This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.

General embryology. Developmental biology --- Histology. Cytology --- Oncology. Neoplasms --- embryologie (biologie) --- oncologie --- cytologie --- embryologie (geneeskunde) --- histologie

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Histology. Cytology --- Oncology. Neoplasms --- oncologie --- cytologie --- histologie