Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The traditional problem of the poor presentability as well as diagnostic and therapeutic practicability of individual patient care is still unresolved. The present book aims at leading the reader (cancer researchers, pharmacologists, biologists) away―in a scientifically accessible manner―from the daily conflicts between theory and practice and between the generalized and individual tumor patient, so that more personalized diagnostic and therapeutic strategies can be developed for controlling metastatic tumor disease: • First, recording the systems concept of tumor biology based on rather different sciences (biochemistry, cell biology, and medical oncology) including their potential contribution to communication, • then, giving reductionistically derived systems features an internal communicative context (formal-pragmatic communication theory), and • finally, binding the systems features to (tumor-immanent) evolutionary processes (modularity of biochemical and cellular processes, rationalization of biologic functions).

Cancer -- Molecular aspects. --- Cancer -- Treatment. --- Drug targeting. --- Pharmacogenomics. --- Tumors --- Cancer --- Therapeutics --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Molecular Targeted Therapy --- Neoplasms --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Oncology --- Growth --- Molecular aspects --- Tumors. --- Cancer cells. --- Molecular aspects. --- Treatment. --- Cancer therapy --- Cancer treatment --- Tumours --- Therapy --- Medicine. --- Cancer research. --- Pharmaceutical technology. --- Medicinal chemistry. --- Oncology. --- Evolutionary biology. --- Medicine & Public Health. --- Medicinal Chemistry. --- Medicine/Public Health, general. --- Cancer Research. --- Pharmaceutical Sciences/Technology. --- Evolutionary Biology. --- Cells --- Pathology, Cellular --- Pathology --- Cysts (Pathology) --- Oncology  . --- Biochemistry. --- Evolution (Biology). --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Biology --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Composition --- Health Workforce --- Cancer research --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Combined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and ‘universal’ biomarkers concertedly address genetically based tumor heterogeneity.

Biology --- Human biochemistry --- Pharmacology. Therapy --- Oncology. Neoplasms --- Pathological biochemistry --- Human medicine --- Biotechnology --- tumoren --- klinische chemie --- medische biochemie --- farmacologie --- biochemie --- biologie --- biomedische wetenschappen --- oncologie --- biotechnologie --- metastase

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The traditional problem of the poor presentability as well as diagnostic and therapeutic practicability of individual patient care is still unresolved. The present book aims at leading the reader (cancer researchers, pharmacologists, biologists) away •in a scientifically accessible manner •from the daily conflicts between theory and practice and between the generalized and individual tumor patient, so that more personalized diagnostic and therapeutic strategies can be developed for controlling metastatic tumor disease: ¢ First, recording the systems concept of tumor biology based on rather different sciences (biochemistry, cell biology, and medical oncology) including their potential contribution to communication, ¢ then, giving reductionistically derived systems features an internal communicative context (formal-pragmatic communication theory), and ¢ finally, binding the systems features to (tumor-immanent) evolutionary processes (modularity of biochemical and cellular processes, rationalization of biologic functions).

Evolution. Phylogeny --- Hygiene. Public health. Protection --- Pharmacology. Therapy --- Oncology. Neoplasms --- Clinical chemistry --- Human medicine --- medische chemie --- farmacologie --- geneeskunde --- gezondheidszorg --- oncologie --- Europees recht