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Recent advances in the pharmaceutical sciences and biotechnology have facilitated the production, design, formulation and use of various types of pharmaceuticals and biopharmaceuticals. This book provides detailed information on the background, basic principles, and components of techniques used for the analysis of pharmaceuticals and biopharmaceuticals. Focusing on those analytical techniques that are most frequently used for pharmaceuticals, it classifies them into three major sections and 19 chapters, each of which discusses a respective technique in detail. Chiefly intended for graduate students in the pharmaceutical sciences, the book will familiarize them with the components, working principles and practical applications of these indispensable analytical techniques.
Drugs --- Analysis. --- Pharmaceutical analysis --- Adulteration and analysis --- Pharmaceutical technology. --- Laboratory medicine. --- Spectroscopy. --- Chromatography. --- Pharmaceutical Sciences/Technology. --- Laboratory Medicine. --- Spectroscopy/Spectrometry. --- Analysis, Chromatographic --- Chromatography --- Analytical chemistry --- Phase partition --- Analysis, Spectrum --- Spectra --- Spectrochemical analysis --- Spectrochemistry --- Spectrometry --- Spectroscopy --- Chemistry, Analytic --- Interferometry --- Optics --- Radiation --- Wave-motion, Theory of --- Absorption spectra --- Light --- Spectroscope --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Qualitative
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This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics. .
Pharmacology. --- Pharmaceutical technology. --- Pharmacology/Toxicology. --- Pharmaceutical Sciences/Technology. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Drug stability. --- Stability, Drug --- Pharmacology --- Stability
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This volume discusses how environmental pollutants are involved in the pathogenesis of neurological disorders, and covers specific mechanisms and risk factors, as well as the necessary strategies to reduce the adverse impacts of environmental pollutants on the human nervous system. With a collection of contributions from experts in environmental pollution, neurology and pharmaceutical chemistry, the book provides both an introduction to the pathogenesis of neurodegeneration, including the types and different classes of neurological disorders, and studies demonstrating the clear link between environmental contaminants (e.g. pesticides, smoking, mycotoxins, persistent organic pollutants (POP's), polychlorinated biphenyls, phthalates, nanomaterials) and the development of neurological disorders in vulnerable populations. The book fills in a gap in research on the topic by also covering state-of-the-art treatment strategies and mitigation measures for each type of pollutant. The book will be of interest to environmental scientists, pharmacologists, toxicologists, biochemists, biotechnologists, and food and drug regulatory organizations.
Environment. --- Neurosciences. --- Environmental chemistry. --- Pharmacology. --- Pollution. --- Environment, general. --- Environmental Chemistry. --- Pharmacology/Toxicology. --- Pollution, general. --- Nervous system --- Nervous System Diseases. --- Environmental Health. --- Chemical pollution --- Chemicals --- Contamination of environment --- Environmental pollution --- Pollution --- Contamination (Technology) --- Asbestos abatement --- Bioremediation --- Environmental engineering --- Environmental quality --- Factory and trade waste --- Hazardous waste site remediation --- Hazardous wastes --- In situ remediation --- Lead abatement --- Pollutants --- Refuse and refuse disposal --- Diseases --- Environmental aspects. --- Environmental aspects --- Environmental Health Science --- Health, Environmental --- Environmental Health Sciences --- Environmental Healths --- Health Science, Environmental --- Health Sciences, Environmental --- Healths, Environmental --- Science, Environmental Health --- Sciences, Environmental Health --- Ecology --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Neurology --- Organs (Anatomy) --- Neurosciences --- Diseases. --- Medical neurology --- Nerves --- Neurologic disorders --- Neurological disorders --- Neuropathology
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Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is a complete and well-integrated reference on their mechanisms of action, their role in diseases, agents responsible for their deactivation, and their malfunction. Chapters explain the biochemistry of DMEs, including biochemical activation, functions, computational approaches, different contaminants on the action and function of DMEs, and describe the importance of DMEs in the drug development process. Conditions covered include metabolic diseases, cardiovascular diseases, neurological diseases, physiological diseases, xenobiotics and inflammatory responses, and their contribution in the malfunctioning of drug metabolizing enzymes.
Enzymes --- Biotransformation (Metabolism) --- Biotechnology. --- Activation, Metabolic --- Bioactivation (Metabolism) --- Biodegradation (Metabolism) --- Metabolic activation --- Metabolism --- Pharmacology --- Enzymology. --- Drugs --- Biotransformation --- Pharmaceutical Preparations --- Metabolism. --- metabolism
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This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics. .
History of human medicine --- Pharmacology. Therapy --- farmacologie
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Recent advances in the pharmaceutical sciences and biotechnology have facilitated the production, design, formulation and use of various types of pharmaceuticals and biopharmaceuticals. This book provides detailed information on the background, basic principles, and components of techniques used for the analysis of pharmaceuticals and biopharmaceuticals. Focusing on those analytical techniques that are most frequently used for pharmaceuticals, it classifies them into three major sections and 19 chapters, each of which discusses a respective technique in detail. Chiefly intended for graduate students in the pharmaceutical sciences, the book will familiarize them with the components, working principles and practical applications of these indispensable analytical techniques.
Theoretical spectroscopy. Spectroscopic techniques --- Fysicochemical separation methods --- Pharmacology. Therapy --- Semiology. Diagnosis. Symptomatology --- Human medicine --- klinische laboratoria --- medische laboratoriumtechnologie --- farmacologie --- spectroscopie --- chromatografie
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This volume discusses how environmental pollutants are involved in the pathogenesis of neurological disorders, and covers specific mechanisms and risk factors, as well as the necessary strategies to reduce the adverse impacts of environmental pollutants on the human nervous system. With a collection of contributions from experts in environmental pollution, neurology and pharmaceutical chemistry, the book provides both an introduction to the pathogenesis of neurodegeneration, including the types and different classes of neurological disorders, and studies demonstrating the clear link between environmental contaminants (e.g. pesticides, smoking, mycotoxins, persistent organic pollutants (POP's), polychlorinated biphenyls, phthalates, nanomaterials) and the development of neurological disorders in vulnerable populations. The book fills in a gap in research on the topic by also covering state-of-the-art treatment strategies and mitigation measures for each type of pollutant. The book will be of interest to environmental scientists, pharmacologists, toxicologists, biochemists, biotechnologists, and food and drug regulatory organizations.
General ecology and biosociology --- History of human medicine --- Neuropathology --- Environmental protection. Environmental technology --- environment --- neurologie --- milieuchemie --- farmacologie --- milieutechnologie --- bindingen (chemie)
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This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.
Ecotoxicology. --- Metabolic diseases. --- Pharmacology. --- Environmental chemistry. --- Metabolic Diseases. --- Pharmacology/Toxicology. --- Environmental Chemistry. --- Chemistry, Environmental --- Chemistry --- Ecology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Diseases --- Ecotoxicology --- Pollutants --- Pollution --- Environmental health --- Toxicology --- Physiological effect --- Metabolism --- Endocrine disrupting chemicals. --- Disorders. --- Disorders --- Treatment. --- Disrupters, Endocrine --- Disrupting chemicals, Endocrine --- Disruptors, Endocrine --- EDCs (Endocrine disrupting chemicals) --- Endocrine disrupters --- Endocrine disrupting compounds --- Endocrine disruptors --- Environmental endocrine disrupters --- Environmental endocrine disrupting chemicals --- Environmental endocrine disruptors --- Hormone disruptors --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology
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History of human medicine --- Pharmacology. Therapy --- farmacologie
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Theoretical spectroscopy. Spectroscopic techniques --- Fysicochemical separation methods --- Pharmacology. Therapy --- Semiology. Diagnosis. Symptomatology --- Human medicine --- klinische laboratoria --- medische laboratoriumtechnologie --- farmacologie --- spectroscopie --- chromatografie
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