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MicroRNAs (miRNAs) are small 22-nucleotides long non-coding RNAs that regulate the gene expression through translational repression and mRNA degradation in varieties of species. miRNAs play regulatory role in several fundamental biological processes from normal development to regulation of stem cells, cancer stem cells and various human diseases including cancer. miRNAs can be used as potential biomarkers for disease diagnosis and have been considered potential therapeutic strategies in cancer treatment. This is a timely and specialized book providing the current understanding of miRNAs and their potential application in cancer diagnosis, prognosis, and therapeutic strategies in cancer treatment. This book will be a valuable source of information for the scientists in the field of cancer research as well as undergraduate and graduate students who want to pursue their research careers in cancer biology.

Cancer --- Biomedicine. --- Genetic aspects. --- Molecular aspects. --- Cancer genetics --- Cancer genes --- Oncology. --- Gene expression. --- Microbiology. --- Medicine. --- Cancer Research. --- Gene Expression. --- Medical Microbiology. --- Biomedicine general. --- Microbial biology --- Biology --- Microorganisms --- Genes --- Genetic regulation --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Expression --- Health Workforce --- Cancer research. --- Medical microbiology. --- Biomedicine, general. --- Cancer research --- Research.

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MicroRNAs (miRNAs) are small 22-nucleotides long non-coding RNAs that regulate the gene expression through translational repression and mRNA degradation in varieties of species. miRNAs play regulatory role in several fundamental biological processes from normal development to regulation of stem cells, cancer stem cells and various human diseases including cancer. miRNAs can be used as potential biomarkers for disease diagnosis and have been considered potential therapeutic strategies in cancer treatment. This is a timely and specialized book providing the current understanding of miRNAs and their potential application in cancer diagnosis, prognosis, and therapeutic strategies in cancer treatment. This book will be a valuable source of information for the scientists in the field of cancer research as well as undergraduate and graduate students who want to pursue their research careers in cancer biology.

Genetics --- General microbiology --- Molecular biology --- Human biochemistry --- Oncology. Neoplasms --- Medical microbiology, virology, parasitology --- Pathological biochemistry --- Human medicine --- medische microbiologie --- medische biochemie --- stamcellen --- biochemie --- biomedische wetenschappen --- microbiologie --- oncologie --- moleculaire biologie --- genexpressie

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This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.

Stem cells. --- MicroRNA. --- Life sciences. --- Cancer research. --- Geriatrics. --- Cell physiology. --- Regenerative medicine. --- Tissue engineering. --- Life Sciences. --- Stem Cells. --- Regenerative Medicine/Tissue Engineering. --- Cell Physiology. --- Cancer Research. --- Geriatrics/Gerontology. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Medicine --- Regeneration (Biology) --- Cell function --- Cytology --- Physiology --- Gerontology --- Older people --- Cancer research --- Biosciences --- Sciences, Life --- Science --- Diseases --- Health and hygiene --- Micro RNA --- miRNA (MicroRNA) --- pre-miRNA (Pre-MicroRNA) --- pri-miRNA (Primary MicroRNA) --- Primary MicroRNA --- Primary miRNA --- Small temporal RNA --- stRNA (Small temporal RNA) --- Antisense RNA --- Non-coding RNA --- Oncology. --- Tumors

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How stem cells behave is very much a factor of their local microenvironment, also known as the stem cell niche. Physical, chemical, or electrical signals from the neighboring cells or biochemical signals from distant cells are crucial in the cell fate decision process. A major challenge of tissue engineering is to mimic the natural cell environment by designing very sophisticated scaffolds able not only to mechanically support cells, but also to release signals biologically relevant for governing stem cell fate. In addition, increasing evidence suggests that abnormal interaction of stem cells with their niche is responsible for altered cell function leading to malignant transformation. This book discusses some of the recent advances in stem cell research that may help understanding the properties of the niche that govern stem cell fate. Technical topics discussed include:Stem cell biologyCancer stem cellsStem cell interactions with biomaterialsEngineering the stem cell microenvironmentStem cells in tissue regeneration and repairThe Disputationes Workshop series is an international initiative aimed at disseminating stem cell related cutting edge knowledge among scientists, healthcare workers, students and policy makers. This book emerges as a result of the scientific contributions presented and discussed during the fifth Disputationes Workshop held in Aalborg (Denmark) in April 2014. The stem cell microenvironment and its role in regenerative medicine and cancer pathogenesis is ideal for academic staff and master/research students in biomedical and health sciences

Carcinogenesis. --- Carcinogens --- Regenerative medicine. --- Regenerative medicine --- Medicine --- Regeneration (Biology) --- Cancer --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathology --- Genetic toxicology --- Pathogenesis --- Cellular biology (cytology) --- Pre-clinical medicine: basic sciences --- Stem cells --- Carcinogenesis --- Research --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells