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Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor but also has other novel pharmacological features which account for its effect in the control of pain and inflammation. It has become a leading NSAID in over 50 countries worldwide. This book provides a comprehensive and fully up-to-date critical review of the published literature on nimesulide, including comparisons with anti-inflammatory, analgesic and antipyretic agents. The emphasis is on the action of nimesulide in relation to its therapeutic and side effects in comparison with other established NSAIDs, including the new class of Coxibs. The chapters are written by leading experts and cover development of nimesulide, including synthesis and production, introduction, and approved uses and applications, followed by pharmacokinetics and toxicological properties, adverse reactions and their mechanisms.

Nimesulide. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect --- Analgesics --- Antipyretics --- Cyclooxygenase 2 --- Nonsteroidal anti-inflammatory agents --- Sulfonamides --- Inhibitors --- Toxicology. --- Pain Medicine. --- Rheumatology. --- Immunology. --- Human physiology. --- Anesthesiology. --- Pharmacology/Toxicology. --- Human Physiology. --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Anaesthesiology --- Surgery --- Human biology --- Physiology --- Human body --- Immunobiology --- Life sciences --- Serology --- Internal medicine --- Connective tissues --- Joints --- Toxicology --- Diseases --- Algiatry --- Pain medicine.

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Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.

Anti-inflammatory agents. --- Ibuprofen. --- Pain -- Treatment. --- Pharmacology. --- Ibuprofen --- Biological Science Disciplines --- Phenylpropionates --- Acids, Carbocyclic --- Natural Science Disciplines --- Disciplines and Occupations --- Carboxylic Acids --- Organic Chemicals --- Chemicals and Drugs --- Pharmacology --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Side effects. --- Isobutylhydratropic acid --- Medicine. --- Immunology. --- Rheumatology. --- Biomedicine. --- Pharmacology/Toxicology. --- Analgesics --- Nonsteroidal anti-inflammatory agents --- Propionic acid --- Derivatives --- Toxicology. --- Internal medicine --- Connective tissues --- Joints --- Immunobiology --- Life sciences --- Serology --- Chemicals --- Medicine --- Poisoning --- Poisons --- Diseases --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Inflammation --- Copper --- Copper --- Zinc --- Zinc --- Zinc --- Copper --- Metal complexes --- Inflammation. --- Degeneration (Pathology) --- Inflammation (Pathologie) --- Dégénérescence (Pathologie) --- drug therapy. --- metabolism. --- therapeutic use. --- metabolism. --- therapeutic use. --- Therapeutic use. --- Therapeutic use. --- Therapeutic use.

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Antiasthmatic agents --- Asthma --- Bronchodilator agents --- Bronchodilator drugs --- Bronchodilators --- Bronchospasmolytic drugs --- Drugs, Bronchodilator --- Drugs, Bronchospasmolytic --- Bronchi --- Respiratory agents --- Bronchial asthma --- Lungs --- Respiratory allergy --- Antasthmatic agents --- Anti-asthma agents --- Anti-asthmatic agents --- Antiasthma agents --- Antiallergic agents --- Congresses --- Chemotherapy&delete& --- drug therapy --- Diseases --- Diseases, Obstructive --- Chemotherapy --- Pharmacology. Therapy --- Allergy --- Pathology of the respiratory system --- Congresses. --- Drug therapy

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Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor but also has other novel pharmacological features which account for its effect in the control of pain and inflammation. It has become a leading NSAID in over 50 countries worldwide. This book provides a comprehensive and fully up-to-date critical review of the published literature on nimesulide, including comparisons with anti-inflammatory, analgesic and antipyretic agents. The emphasis is on the action of nimesulide in relation to its therapeutic and side effects in comparison with other established NSAIDs, including the new class of Coxibs. The chapters are written by leading experts and cover development of nimesulide, including synthesis and production, introduction, and approved uses and applications, followed by pharmacokinetics and toxicological properties, adverse reactions and their mechanisms.

Immunology. Immunopathology --- Human physiology --- Anesthesiology --- Pharmacology. Therapy --- Pathology of the organs of movement --- immunologie --- farmacologie --- anesthesie --- toxicologie --- reumatologie --- analgesie --- pijn --- fysiologie