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This book fills in a gap in the NO literature. Recent progress in the field of NO-biology shows that NO is generated within distinct cell compartments, including specific plasma membrane regions, mitochondria, chloroplasts, peroxisomes, the Golgi-complex and intracellular membrane systems. NO synthesis plays specific roles in these compartments and, in turn, cell organelles also control intracellular NO levels. This monograph focuses on the roles played by the subcellular NO-signaling microdomains in the prokaryote-, fungus-, plant- and animal cells and shows how NO behaves as an intracellular signal in distinct cellular environments. This monograph also provides a summary of our knowledge on how NO synthesis came through evolution to be associated with organelles and subcellular compartments. Promotes the novel ideas that some functions of NO and its associations with subcellular units have been conserved during the evolution of the cell. A special chapter is dedicated to the biomedical relevance of subcellular NO synthesis, and this chapter also discusses the evidence that altered compartmentalization of NO-producing enzymes causes disease.

Nitric oxide -- Physiological effect. --- Nitrous oxide. --- Nitric oxide --- Cell organelles --- Cell physiology --- Botany --- Earth & Environmental Sciences --- Plant Physiology --- Physiological effect --- Physiological effect. --- Pathophysiology. --- Endothelial relaxing factor --- Endothelium-derived relaxing factors --- Nitrogen oxide --- Medicine. --- Molecular biology. --- Biochemistry. --- Plant biochemistry. --- Cell biology. --- Zoology. --- Biomedicine. --- Biomedicine general. --- Molecular Medicine. --- Cell Biology. --- Animal Biochemistry. --- Plant Biochemistry. --- Neurotransmitters --- Nitrogen compounds --- Oxides --- Cytology. --- Biology --- Natural history --- Animals --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Composition --- Health Workforce --- Biomedicine, general. --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Phytochemicals --- Plant biochemical genetics --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology

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Histology. Cytology --- Molecular biology --- Animal biochemistry --- Zoology --- Human biochemistry --- Biochemical engineering --- medische biochemie --- biochemie --- cytologie --- histologie --- zoölogie --- planten --- moleculaire biologie

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Histology. Cytology --- General biochemistry --- Immunology. Immunopathology --- Human physiology --- Infectious diseases. Communicable diseases --- immunologie --- lipiden --- besmettelijke ziekten --- fysiologie --- cytologie --- histologie