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In this stunning work chronicling the author’s exploration of his own past—and the lives of many hundreds of thousands of nameless immigrants who struggled alongside his own ancestors—Peter Quinn paints a brilliant new portrait of the Irish-American men and women whose evolving culture and values continue to play such a central role in all of our identities as Americans. In Quinn’s hands, the Irish stereotype of “Paddy” gives way to an image of “Jimmy”—an archetypal Irish-American. From Irish immigration to modern politics, Quinn vibrantly weaves together the story of a remarkable people and their immeasurable contribution to American history and culture.

Catholics --- Immigrants --- History.

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Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either glycerol or sphingosine. The fatty acids themselves constitute an important reservoir of substrates for conversion into families of signalling and modulating molecules including the eicosanoids amongst which are the prostaglandins, thromboxanes and leucotrienes. The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume. This section also deals with the modulation of protein function and inflammation by unsaturated fatty acids and their derivatives. New insights into the role of fatty acid synthesis and eicosenoid function in tumour progression and metastasis are presented.

Lipids. --- Lipids --- Metabolism. --- Lipides --- Lipins --- Lipoids --- Biomolecules --- Steroids --- Lipid metabolism --- Human physiology. --- Medicine. --- Biochemistry. --- Human Physiology. --- Biomedicine general. --- Biochemistry, general. --- Lipidology. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Human biology --- Physiology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Composition --- Biomedicine, general. --- Health Workforce --- Medicine --- Biomedical Research. --- Research. --- Biological research --- Biomedical research