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Proceedings of the XIVth International Symposium on Arterial Chemoreception, held June 24-28, 1999, in Philadelphia, Pennsylvania. This volume, containing the proceedings of the fourteenth biannual ISAC meeting presents a new departure from their traditional focus on arterial chemoreceptors and their functions, in the expansion to include the study and discussion of oxygen sensing in other tissues and cells, and the genes involved. Bringing together scientists from cellular and systemic boundaries of physiology, working at the interface of cellular and molecular biology, this book, containing new physiological and biochemical perspectives.

Carotid body -- Congresses. --- Chemoreceptors -- Congresses. --- Oxygen -- Metabolism -- Congresses. --- Chemoreceptors --- Carotid body --- Carotid Body --- Chemoreceptor Cells --- Respiratory Physiological Phenomena --- Sensory Receptor Cells --- Paraganglia, Nonchromaffin --- Neurons, Afferent --- Medicine. --- Neurosciences. --- Pharmacology. --- Biochemistry. --- Biophysics. --- Biological physics. --- Biomedicine. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Biophysics and Biological Physics. --- Oxygen --- Metabolism --- Congresses --- Toxicology. --- Biological and Medical Physics, Biophysics. --- Biological physics --- Biology --- Medical sciences --- Physics --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Composition --- Physiological effect --- Chalcogens --- Nonmetals --- Photosynthetic oxygen evolution --- Carotid gland --- Carotid glomus --- Glomus caroticum --- Intercarotid body --- Nodulus caroticus --- Nonchromaffin paraganglia --- Respiration --- Regulation

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Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic level hypoxia and carotid body function. This volume summarises the proceedings of the XIXth meeting of the Society, held in Leeds, UK during the summer of 2014. As such this volume represents a unique collection of state of the art reviews and original, brief research articles covering all aspects of oxygen sensing, ranging from the molecular mechanisms of chemotransduction in oxygen sensing cells such as the carotid body type I cells, to the adverse, reflex cardiovascular outcomes arising from carotid body dysfunction as seen, for example, in heart failure or obstructive sleep apnoea. This volume will be of tremendous interest to basic scientists with an interest in the cellular and molecular biology of oxygen sensing and integrative, whole organism physiologists as well as physicians studying or treating the clinical cardiovascular consequences of carotid body dysfunction.

Biomedicine. --- Human Physiology. --- Pharmacology/Toxicology. --- Laboratory Medicine. --- Gene Expression. --- Molecular Medicine. --- Neurosciences. --- Medicine. --- Gene expression. --- Human physiology. --- Medical laboratories. --- Toxicology. --- Médecine --- Expression génique --- Physiologie humaine --- Neurosciences --- Toxicologie --- Physiology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Carotid body --- Chemoreceptors --- Cardiopulmonary system --- Cardiopneumatic system --- Cardiorespiratory system --- Pneumocardial system --- Carotid gland --- Carotid glomus --- Glomus caroticum --- Intercarotid body --- Nodulus caroticus --- Laboratory medicine. --- Molecular biology. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology --- Human biology --- Human body --- Genes --- Genetic regulation --- Clinical sciences --- Medical profession --- Life sciences --- Physicians --- Physiological effect --- Expression --- Organs (Anatomy) --- Nonchromaffin paraganglia --- Respiration --- Regulation --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Health Workforce

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Arterial chemoreceptors are unique structures which continuously monitor changes in arterial blood oxygen, carbon dioxide, glucose, and acid.  Alterations in these gases are almost instantaneously sensed by arterial chemoreceptors and relayed into a physiological response which restores blood homeostasis.  Arterial Chemoreception contains updated material regarding the physiology of the primary arterial chemoreceptor; the carotid body.  Moreover, this book also explores tantalizing evidence regarding the contribution of the aortic bodies, chromaffin cells, lung neuroepithelial bodies, and brainstem areas involved in monitoring changes in blood gases.  Furthermore this collection includes data showing the critical importance of these chemoreceptors in the pathophysiology of human disease and possible therapeutic treatments. This book is a required text for any researcher in the field of arterial chemoreception for years to come.  It is also a critical text for physicians searching for bench-to-bedside treatments for heart failure, sleep apnea, and pulmonary hypertension.     

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Every three years, the International Society for Arterial Chemoreception (ISAC) arranges a Meeting to bring together all of the major International research groups investigating the general topic of oxygen sensing in health and disease, with a prime focus upon systemic level hypoxia and carotid body function. This volume summarises the proceedings of the XIXth meeting of the Society, held in Leeds, UK during the summer of 2014. As such this volume represents a unique collection of state of the art reviews and original, brief research articles covering all aspects of oxygen sensing, ranging from the molecular mechanisms of chemotransduction in oxygen sensing cells such as the carotid body type I cells, to the adverse, reflex cardiovascular outcomes arising from carotid body dysfunction as seen, for example, in heart failure or obstructive sleep apnoea. This volume will be of tremendous interest to basic scientists with an interest in the cellular and molecular biology of oxygen sensing and integrative, whole organism physiologists as well as physicians studying or treating the clinical cardiovascular consequences of carotid body dysfunction.

Genetics --- Molecular biology --- History of human medicine --- Human physiology --- Pharmacology. Therapy --- Semiology. Diagnosis. Symptomatology --- Neuropathology --- Human medicine --- klinische laboratoria --- neurologie --- medische laboratoriumtechnologie --- farmacologie --- toxicologie --- fysiologie --- moleculaire biologie --- genexpressie