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The second volume of the book-Protein-Protein Interactions (PPIs) provides an overview of various protein-protein interactions (PPIs) that are involved in various human diseases including cancer, neurodegenerative diseases, immune diseases, and inflammation. It summarizes the structure and ligand-based drug designing approaches for the discovery of small molecules that can inhibit PPIs in these diseases. The book discusses different computational and experimental tools that are used to determine the anomalous interactions underlying the diseases. Lastly, it also reviews the classical interactions between pathogens and hosts that are responsible for the pathophysiology of infectious diseases.

Protein-protein interactions. --- Interactions, Protein-protein --- PPIs (Protein-protein interactions) --- Protein interactions --- Interactomes --- Molecular association --- Bioinformatics. --- Life sciences. --- Medicine --- Biology --- Neurosciences. --- Life Sciences. --- Biomedical Research. --- Neuroscience. --- Research. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Biological research --- Biomedical research --- Health Workforce --- Biosciences --- Sciences, Life --- Science --- Bio-informatics --- Biological informatics --- Information science --- Computational biology --- Systems biology --- Data processing

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This brief provides a broad overview of protein-engineering research, offering a glimpse of the most common experimental methods. It also presents various computational programs with applications that are widely used in directed evolution, computational and de novo protein design. Further, it sheds light on the advantages and pitfalls of existing methodologies and future perspectives of protein engineering techniques.

Biomathematics. Biometry. Biostatistics --- Molecular biology --- Human biochemistry --- Pharmacology. Therapy --- Applied physical engineering --- Biotechnology --- Programming --- Artificial intelligence. Robotics. Simulation. Graphics --- neuronale netwerken --- fuzzy logic --- medische biochemie --- cybernetica --- bio-engineering --- bio-informatica --- farmacologie --- biotechnologie --- biometrie --- KI (kunstmatige intelligentie) --- ingenieurswetenschappen --- moleculaire biologie --- AI (artificiële intelligentie)

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This book provides a comprehensive overview of the fundamental aspects of protein-protein interactions (PPI), including a detailed account of the energetics and thermodynamics involved in these interactions. It also discusses a number of computational and experimental approaches for the prediction of PPI interactions and reviews their principles, advantages, drawbacks, and the recent developments. Further, it offers structural and mechanistic insights into the formation of protein-protein complexes and maps different PPIs into networks to delineate various pathways that operate at the cellular level. Lastly, it describes computational protein-protein docking techniques and discusses their implications for further experimental research. Given its scope, this book is a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.

Chemistry --- Biomathematics. Biometry. Biostatistics --- bio-informatica --- proteïnen

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Biomathematics. Biometry. Biostatistics --- Biology --- Pathological biochemistry --- Neuropathology --- Human medicine --- medische biochemie --- neurologie --- bio-informatica --- biologie --- biomedische wetenschappen --- geneeskunde