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Experience is inescapably temporal. But how do we experience time? Temporal experience is a fundamental subject in philosophy - according to Husserl, the most important and difficult of all. Its puzzles and paradoxes were of critical interest from the Early Moderns through to the Post-Kantians. After a period of relative neglect, temporal experience is again at the forefront of debates across a wealth of areas, from philosophy of mind and psychology, to metaphysics and aesthetics. The Routledge Handbook of Philosophy of Temporal Experience is an outstanding reference source to the key debates in this exciting subject area and represents the first collection of its kind. Comprising nearly 30 chapters by a team of international contributors, the Handbook is organized into seven clear parts: * Ancient and early modern perspectives * Nineteenth and early twentieth-century perspectives * The structure of temporal experience * Temporal experience and the philosophy of mind * Temporal experience and metaphysics * Empirical perspectives * Aesthetics Within each part, key topics concerning temporal experience are examined, including canonical figures such as Locke, Kant and Husserl; extensionalism, retentionalism and the specious present; interrelations between temporal experience and time, agency, dreaming, and the self; empirical theories of perceiving and attending to time; and temporal awareness in the arts including dance, music and film. The Routledge Handbook of Philosophy of Temporal Experience is essential reading for students and researchers of philosophy of mind and psychology. It is also extremely useful for those in related fields such as metaphysics, phenomenology and aesthetics, as well as for psychologists and cognitive neuroscientists.

Experience. --- Time. --- Expérience --- Temps --- Expérience. --- Temps. --- Expérience.

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These subject-specific core texts are for beginning secondary teachers following postgraduate certificate in education graduate teacher programme or undergraduate routes into teaching.

History --- Study and teaching (Secondary)

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For this second edition of their much praised Cytochrome P450, the editors have collected accounts of the essential core techniques that use the latest methodologies for the investigation of P450s. Highlights include protocols for spectral analysis and purification of P450s, enzymatic assays of P450s and flavin-containing monooxygenases (FMOs), expression of P450s and FMOs in heterologous systems, and the production and use of antipeptide antibodies. Additional chapters contain readily reproducible techniques for the transfection of hepatocytes for gene regulation studies, P450 reporter gene assays, in situ hybridization, and analysis of genetic polymorphisms. Also described are techniques for the generation of mice with targeted gene disruptions. Although the emphasis is on P450s of mammalian origin, many of the readily reproducible methods described are suitable for P450s from any source. Each chapter is written by researchers who have been involved in the development and application of the particular technique to P450s or FMOs. The protocols are presented in a step-by-step manner, with extensive cross-references to notes that highlight critical steps, potential problems, and alternative methods so that the researcher can understand the basis of the method and perform it successfully. Cutting-edge and highly practical, Cytochrome P450, Second Edition provides both novices and experienced researchers across many fields all the tools needed today to elucidate the crucial biological role played by cytochrome P450 in the metabolism of therapeutic drugs, chemical carcinogens, and environmental pollutants.

Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition

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Antibiotica. (Congres) --- Antibiotiques. (Congrès) --- Chimiothérapie. (Congrès) --- Chemotherapie. (Congres)