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Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma. .
Mitochondrial pathology. --- Lungs --- Diseases --- Molecular aspects. --- Lung --- Cardiopulmonary system --- Chest --- Respiratory organs --- Mitochondria --- Mitochondrial disorders --- Metabolism --- Pathology, Cellular --- Pathology --- Disorders --- Pneumology. --- Internal medicine. --- Medicine. --- Pneumology/Respiratory System. --- Internal Medicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Medicine, Internal --- Medicine --- Health Workforce --- Respiratory organs—Diseases. --- Biomedicine, general.
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Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma. .
Human biochemistry --- Physiology of the respiratory system --- Pathology of the respiratory system --- Human medicine --- klinische chemie --- medische biochemie --- COPD (chronic obstructive pulmonary disease) --- biochemie --- geneeskunde --- toxicologie --- pneumologie --- astma
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This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
Oxidative stress. --- Systems biology. --- Cell cycle. --- Oxidative Stress. --- Systems Biology. --- Cell Cycle Analysis. --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Oxidation-reduction reaction --- Stress (Physiology) --- Mitotic cycle --- Nuclear cycle (Cytology) --- Biological rhythms --- Oxidació fisiològica --- Sistemes biològics --- Biosistemes --- Teoria de sistemes --- Sistemes de control biològic --- Vida artificial --- Biologia de sistemes --- Oxidació biològica --- Bioquímica --- Cicle de la pentosa-fosfat
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Cardiovascular system --- Cellular signal transduction. --- Diseases. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cardiovascular diseases --- Sistema cardiovascular --- Malalties cardiovasculars
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This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
Histology. Cytology --- Biology --- Immunology. Immunopathology --- Biotechnology --- anti-oxidantia --- vrije radicalen --- biologie --- cytologie --- celprocessen --- immunochemie --- enzymen
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This contributed volume focuses on cardiovascular diseases (CVDs), and explores the ways in which signaling mechanisms at the biochemical, molecular, and cellular levels in the blood vessels (vascular) and heart contribute to the underlying causes of development and progression of the CVDs. This volume covers unique topics such as oxidant signaling in vascular and heart diseases and health, cytoskeletal signaling in vascular health and disease, phospholipase signaling in CVDs, lipid signaling in vascular and myocardial health and diseases, and drug discovery in cellular signaling for cardiovascular diseases. This book assembles the most important discoveries made by leaders on the cellular signaling mechanisms operating behind the development and progression of life-threatening CVDs. It is an extremely useful resource for the investigators in the field of CVDs, and opens the discussion for further discovery of efficient management and effective treatment of the CVDs.
Molecular biology --- General biophysics --- Human biochemistry --- Blood physiology. Circulatory physiology --- Human physiology --- Pathological biochemistry --- Biotechnology --- medische biochemie --- biofysica --- bio-engineering --- biochemie --- biotechnologie --- fysiologie --- bloedsomloop --- moleculaire biologie
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Cardiovascular system --- Cellular signal transduction. --- Diseases. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cardiovascular diseases
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Histology. Cytology --- Biology --- Immunology. Immunopathology --- Biotechnology --- anti-oxidantia --- vrije radicalen --- biologie --- cytologie --- celprocessen --- immunochemie --- enzymen
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This is the second volume of the comprehensive, two-volume work on oxidative stress in lung diseases. Adopting a multidisciplinary approach, it demonstrates the cellular and molecular mechanisms associated with ROS (reactive oxygen species)-induced initiation and progression of a variety of lung diseases, such as COPD, emphysema, asthma, cystic fibrosis, occupational pulmonary diseases and pulmonary hypertension and discusses points for therapeutic intervention. The book also covers translational research and the latest research on prevention and therapeutics. Each chapter includes in-depth insights into the mechanisms associated with lung diseases and into identifying targets for drug development. Bridging the gap between fundamental and translational research, and examining applications in the biomedical and pharmaceutical industry, it is a thought- provoking read for basic and applied scientists engaged in biomedical research.
Lungs --- Pulmonary diseases --- Diseases. --- Oxidative stress. --- Respiratory organs—Diseases. --- Medical biochemistry. --- Biomedical engineering. --- Oxidative Stress. --- Pneumology/Respiratory System. --- Medical Biochemistry. --- Biomedical Engineering/Biotechnology. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Oxidation-reduction reaction --- Stress (Physiology)
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In recent years there has been a growing demand to achieve more rapid and accurate detection of RONs (reactive oxygen and nitrogen species), which affect normal physiological processes and pathological conditions, and also of redox stress. In Free Radicals and Antioxidant Protocols, Second Edition, world-renowned researchers respond to this need, considering the most recent analytical and technological aspects of the detection and determination of RONs, and of oxidative, nitrative, nitrosative, and redox stress in biological systems in vivo and in vitro. Chapters include protocols to establish biomarkers for the oxidative stress-induced genetic damage in cellular and animal models, provide novel methods and technologies for analyzing peroxidized lipids, describe techniques for gene therapy, and present methods of EPR imaging of free radicals and oxygen in vivo. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and user-friendly, Free Radicals and Antioxidant Protocols, Second Edition, is an essential guide for the novice and expert researcher alike.
Biochemistry. --- Analytical biochemistry. --- Cytology. --- Biochemistry, general. --- Analytical Chemistry. --- Oxidative Stress. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Analytic biochemistry --- Biochemistry --- Chemistry, Analytic --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Composition --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytical chemistry
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