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Ulcerative colitis (UC) is one of the major forms of inflammatory bowel disease (IBD). Epidemiological trends suggest an initial rise in the incidence of UC, followed by Crohn's disease (CD), in areas where IBD is emerging. As understanding of aspects of the disease is evolving, this book covers new perspectives on the etiology, clinical manifestations, diagnosis, and management of UC. Genetic predisposition, along with gut dysbiosis and environmental factors, triggers the altered gut permeability and dysregulated immune activation that leads to the development of UC, which can manifest both intestinally and extra-intestinally. Platelets play a significant role in augmenting inflammation. Histological examination is important for accurate diagnosis and for distinguishing mimics. Histological remission is an emerging treatment target strategy in UC. Novel treatments include dietary manipulation with anti-inflammatory dietary components like fermented rice bran. A number of challenges need to be addressed in treating special populations like children and pregnant women. Finally, interventional endoscopy is playing an emerging role in the management of colitis-associated neoplasia and postoperative complications and acting as a bridge between surgery and medical therapy. Ulcerative Colitis - Etiology, Diagnosis, Diet, Special Populations, and the Role of Interventional Endoscopy aims to act as a ready reference for the clinician. It provides indispensable updates on several relevant issues in the diagnosis and management of ulcerative colitis and has benefited from the collaboration of leading experts in various aspects of the disease. It aims to facilitate decision-making by gastroenterologists, IBD specialists, interventional endoscopists, dieticians, pathologists, surgeons, and pediatricians treating UC patients.
Ulcerative colitis. --- Colitis --- Inflammatory bowel diseases
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Ulcerative colitis (UC) is one of the major forms of inflammatory bowel disease (IBD). Epidemiological trends suggest an initial rise in the incidence of UC, followed by Crohn's disease (CD), in areas where IBD is emerging. As understanding of aspects of the disease is evolving, this book covers new perspectives on the etiology, clinical manifestations, diagnosis, and management of UC. Genetic predisposition, along with gut dysbiosis and environmental factors, triggers the altered gut permeability and dysregulated immune activation that leads to the development of UC, which can manifest both intestinally and extra-intestinally. Platelets play a significant role in augmenting inflammation. Histological examination is important for accurate diagnosis and for distinguishing mimics. Histological remission is an emerging treatment target strategy in UC. Novel treatments include dietary manipulation with anti-inflammatory dietary components like fermented rice bran. A number of challenges need to be addressed in treating special populations like children and pregnant women. Finally, interventional endoscopy is playing an emerging role in the management of colitis-associated neoplasia and postoperative complications and acting as a bridge between surgery and medical therapy. Ulcerative Colitis - Etiology, Diagnosis, Diet, Special Populations, and the Role of Interventional Endoscopy aims to act as a ready reference for the clinician. It provides indispensable updates on several relevant issues in the diagnosis and management of ulcerative colitis and has benefited from the collaboration of leading experts in various aspects of the disease. It aims to facilitate decision-making by gastroenterologists, IBD specialists, interventional endoscopists, dieticians, pathologists, surgeons, and pediatricians treating UC patients.
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Ulcerative colitis (UC) is one of the major forms of inflammatory bowel disease (IBD). Epidemiological trends suggest an initial rise in the incidence of UC, followed by Crohn's disease (CD), in areas where IBD is emerging. As understanding of aspects of the disease is evolving, this book covers new perspectives on the etiology, clinical manifestations, diagnosis, and management of UC. Genetic predisposition, along with gut dysbiosis and environmental factors, triggers the altered gut permeability and dysregulated immune activation that leads to the development of UC, which can manifest both intestinally and extra-intestinally. Platelets play a significant role in augmenting inflammation. Histological examination is important for accurate diagnosis and for distinguishing mimics. Histological remission is an emerging treatment target strategy in UC. Novel treatments include dietary manipulation with anti-inflammatory dietary components like fermented rice bran. A number of challenges need to be addressed in treating special populations like children and pregnant women. Finally, interventional endoscopy is playing an emerging role in the management of colitis-associated neoplasia and postoperative complications and acting as a bridge between surgery and medical therapy. Ulcerative Colitis - Etiology, Diagnosis, Diet, Special Populations, and the Role of Interventional Endoscopy aims to act as a ready reference for the clinician. It provides indispensable updates on several relevant issues in the diagnosis and management of ulcerative colitis and has benefited from the collaboration of leading experts in various aspects of the disease. It aims to facilitate decision-making by gastroenterologists, IBD specialists, interventional endoscopists, dieticians, pathologists, surgeons, and pediatricians treating UC patients.
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Crohn's disease (CD) is a subtype of inflammatory bowel disease (IBD) that can affect any part of the intestine and can lead to stricture, fistula, and abscess if left untreated. This book highlights the key aspects of the current state of the art of pathogenesis, diagnosis, and therapy for CD and its unique complications. CD has evolved from clinical observations to a network of advanced therapies and quality of care. Among the pathogenetic factors, a significant proportion of the latest research is focused on the gut microbiome, as rapidly changing environmental factors exert their effects primarily by altering the microbiome. This book highlights the enigmatic crosstalk between the gut microbiome and CD. Going further, CD is a great mimicker that is important to differentiate from other diseases, especially intestinal tuberculosis, which is still a significant problem in tuberculosis-endemic countries. This book addresses this issue as well. Among the diagnostic modalities, capsule endoscopy is a non-invasive, radiation-free, and accurate modality for pan-enteric evaluation. The book examines the role of capsule endoscopy in suspected and established CD, including its pros and cons in these scenarios. It also highlights technical advancements in the field. Among the complications of CD, the most dreaded is fistula. Apart from traditional medical and surgical therapies, interventional inflammatory bowel disease (IIBD) therapies like endoscopic fistulotomy and abscess drainage can decrease surgical morbidity and improve patient outcomes. The book reviews the current role and details of such therapies. Overall, this book provides insights into current advances in CD pathogenesis, diagnosis, and management.
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Ulcerative colitis (UC) is one of the major forms of inflammatory bowel disease (IBD). Epidemiological trends suggest an initial rise in the incidence of UC, followed by Crohn's disease (CD), in areas where IBD is emerging. As understanding of aspects of the disease is evolving, this book covers new perspectives on the etiology, clinical manifestations, diagnosis, and management of UC. Genetic predisposition, along with gut dysbiosis and environmental factors, triggers the altered gut permeability and dysregulated immune activation that leads to the development of UC, which can manifest both intestinally and extra-intestinally. Platelets play a significant role in augmenting inflammation. Histological examination is important for accurate diagnosis and for distinguishing mimics. Histological remission is an emerging treatment target strategy in UC. Novel treatments include dietary manipulation with anti-inflammatory dietary components like fermented rice bran. A number of challenges need to be addressed in treating special populations like children and pregnant women. Finally, interventional endoscopy is playing an emerging role in the management of colitis-associated neoplasia and postoperative complications and acting as a bridge between surgery and medical therapy. Ulcerative Colitis - Etiology, Diagnosis, Diet, Special Populations, and the Role of Interventional Endoscopy aims to act as a ready reference for the clinician. It provides indispensable updates on several relevant issues in the diagnosis and management of ulcerative colitis and has benefited from the collaboration of leading experts in various aspects of the disease. It aims to facilitate decision-making by gastroenterologists, IBD specialists, interventional endoscopists, dieticians, pathologists, surgeons, and pediatricians treating UC patients.
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