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Animal Cell Biotechnology: Methods and Protocols, Second Edition constitutes a comprehensive manual of state-of-the-art and new techniques for setting up mammalian cell lines for production of biopharmaceuticals, and for optimizing critical parameters for cell culture considering the whole cascade from lab to final production. The volume is divided into five parts that reflect the processes required for different stages of production. In Part I, basic techniques for establishment of production cell lines are addressed, especially transduction techniques, cells for gene therapy and antibody production. Part II addresses basic cultivation techniques, such as microcarrier culture and encapsulation. Part III covers cell characterization and analysis, including flow cytometric applications, NMR-based techniques, and biochemical and cytometric techniques. Part IV details cultivation techniques, such as disposable bioreactors, hollow fiber cell culture, fixed bed reactors, and configuration of bioreactors. Part V covers downstream techniques such as membrane filtration techniques, while Part VI describes special applications, including retroviral vectors. Animal Cell Biotechnology: Methods and Protocols, Second Edition provides a compendium of techniques for scientists in industrial and research laboratories that use mammalian cells for biotechnology purposes.

Biotechnology. --- Cytology. --- Animal genetics. --- Toxicology. --- Cell Biology. --- Animal Genetics and Genomics. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Genetics --- Cell biology --- Cellular biology --- Biology --- Cells --- Chemical engineering --- Genetic engineering --- Toxicology

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This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.

Biological techniques --- Histology. Cytology --- Human biochemistry --- Pharmacology. Therapy --- Pathological biochemistry --- Human medicine --- Biotechnology --- medische biochemie --- biologische technieken --- bio-engineering --- biomedische wetenschappen --- geneeskunde --- biotechnologie --- cytologie --- histologie --- Cell culture. --- Cell culture --- Cultures (Biology) --- Cytology --- Technique --- Medicine --- Biology --- Cytology. --- Regenerative medicine. --- Biomedical engineering. --- Biomedical Research. --- Cell Biology. --- Biological Techniques. --- Regenerative Medicine and Tissue Engineering. --- Biomedical Engineering and Bioengineering. --- Research. --- Technique. --- Cell biology --- Cellular biology --- Cells --- Biological research --- Biomedical research --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Health Workforce --- Regeneration (Biology)

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J. S. Hayes E. M. Czekanska R. G. Richards The Cell-Surface Interaction Stefanie Michaelis Rudolf Robelek achim Wegener Studying Cell-Surface Interactions In Vitro: A Survey of Experimental Approaches and Techniques Kyobum Kim Diana M. Yoon Antonios G. Mikos F. Kurtis Kasper Harnessing Cell-Biomaterial Interactions for Osteochondral Tissue Regeneration Mathias Wilhelmi Bettina Giere Michael Harder Interaction of Cells with Decellularized Biological Materials Arie Bruinink Reto Luginbuehl Evaluation of Biocompatibility Using In Vitro Methods: Interpretation and Limitations Margit Schulze Edda Tobiasch Artificial Scaffolds and Mesenchymal Stem Cells for Hard Tissues Julia Will Lutz-Christian Gerhardt Aldo R. Boccaccini Bioactive Glass-Based Scaffolds for Bone Tissue Engineering Tali Re’em Smadar Cohen Microenvironment Design for Stem Cell Fate Determination Sonja Kress Anne Neumann Birgit Weyand Cornelia Kasper Stem Cell Differentiation Depending on Different Surfaces Frank Witte Ivonne Bartsch Elmar Willbold Designing the Biocompatibility of Biohybrids K. Wiegandt C. Goepfert R. Pörtner R. Janssen Interaction of Cartilage and Ceramic Matrix Debarun Das Ziyang Zhang Thomas Winkler Meenakshi Mour Christina I. Günter Michael M. Morlock Hans-Günther Machens Arndt F. Schilling Bioresorption and Degradation of Biomaterials.

Cell Physiological Processes --- Culture Techniques --- Clinical Laboratory Techniques --- Cell Physiological Phenomena --- Phenomena and Processes --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Cell Communication --- Cell Culture Techniques --- Tissue Engineering --- Mechanical Engineering --- Engineering & Applied Sciences --- Bioengineering --- Tissue engineering. --- Cell culture. --- Chemistry. --- Biotechnology. --- Cell biology. --- Biomaterials. --- Cell Biology. --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Chemical engineering --- Genetic engineering --- Physical sciences --- Cultures (Biology) --- Cytology --- Regenerative medicine --- Tissue culture --- Technique --- Cytology. --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials)