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This dissertation explores the molecular mechanisms by which resin acids and their derivatives influence the opening of potassium channels, specifically the Shaker Kv channel. The research aims to identify potential drug candidates for conditions like epilepsy by modulating voltage-gated ion channels. The study highlights the role of resin acids as electrostatic openers of these channels, providing insights into their structure-activity relationship. Using techniques such as mutagenesis and molecular docking, the research identifies a novel binding site for small-molecule compounds, showing promise for future drug development. The work is primarily intended for researchers and professionals in pharmacology and neuroscience.

Potassium channels. --- Ion channels. --- Potassium channels --- Ion channels