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Serotonin is an ancient neurotransmitter system involved in various systems and functions in the body and plays an important role in health and disease. The present volume illustrates the broadness of the involvement of serotonergic activity in many processes, focusing particularly on disorders of the brain, including depression, stress and fear, Alzheimer's disease, aggression, sexual behavior, and neuro-immune disorders. Chapters illustrate techniques and methods used to study the complex role of the serotonergic system in all kinds of processes, present new hypotheses for several brain disorders like sleep and depression, and use mathematical modeling as a tool to advance knowledge of the extremely complex brain and body processes.

Serotonin. --- Serotonin --- Mechanism of action.

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Sexual dysfunctions have a high prevalence in males and females, and an increase in research into its backgrounds, causes and treatment is clearly visible. Characterization of sexual dysfunctions is complex and often needs extensive clinical, psychological and psychiatric expertise to arrive at reliable diagnoses. The present volume illustrates various aspects involved in sexual (dys)functioning but also the complexity of the field. Premature ejaculation, erectile dysfunction, female interest/arousal disorder, hypogonadism, sexual side effects of antidepressants and circumcision are subject of the various contributions. The topics treated nicely illustrate the problems associated with sexual function and dysfunction, including lifestyle, biological, mental, sociocultural and religious aspects. The topics in this volume clearly demonstrate the importance of research on sexual functions and dysfunctions.

Sexual Dysfunction, Physiological. --- Sex Disorders --- Sexual Disorders, Physiological --- Sexual Dysfunctions, Physiological --- Physiological Sexual Disorder --- Physiological Sexual Disorders --- Physiological Sexual Dysfunction --- Physiological Sexual Dysfunctions --- Sexual Disorder, Physiological --- Sexual Health --- Medicine --- Sexology --- Urology --- Health Sciences

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An international group of authors have produced an overview of the progress made in the medicinal chemistry of compounds (selectively) acting at serotonin receptors or serotonin transporters either as agonists, partial agonists or antagonists. Structure - affinity relationships and structure - activity relationships of agonists, partial agonists, and antagonists of 5-HT receptors and uptake sites, are discussed. Structure, sequence homology and the effect of site-directed mutations of 5-HT receptors and the reuptake site on the binding of ligands show the tremendous impact of molecular biolo

Serotonin --- Antagonists, Serotonin --- Antiserotonergic agents --- Antiserotonin drugs --- Serotonin antagonists --- Serotonin blockaders --- Serotonin inhibitors --- 5-HT (Neurotransmitter) --- Hydroxytryptamine --- Neurotransmitters --- Tryptamine --- Receptors. --- Agonists. --- Antagonists.

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Farmaceutisch onderzoek. (Congres) --- Psychofarmacologie. (Congres) --- Animaux. Agressivité. (Congrès) --- Pharmacologie. Recherche scientifique. (Congrès) --- Psychopharmacologie. (Congrès) --- Dieren. Agressiviteit. (Congres)