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This book presents the fundamental physics of optical interferometry as applied to biophysical, biological and medical research. Interference is at the core of many types of optical detection and is a powerful probe of cellular and tissue structure in interfererence microscopy and in optical coherence tomography. It is also the root cause of speckle and other imaging artefacts that limit range and resolution. For biosensor applications, the inherent sensitivity of interferometry enables ultrasensitive detection of molecules in biological samples for medical diagnostics. In this book, emphasis is placed on the physics of light scattering, beginning with the molecular origins of refraction as light propagates through matter, and then treating the stochastic nature of random fields that ultimately dominate optical imaging in cells and tissue. The physics of partial coherence plays a central role in the text, with a focus on coherence detection techniques that allow information to be selectively detected out of incoherent and heterogeneous backgrounds. Optical Interferometry for Biology and Medicine is divided into four sections. The first covers fundamental principles, and the next three move up successive scales, beginning with molecular interferometry (biosensors), moving to cellular interferometry (microscopy), and ending with tissue interferometry (biomedical). An outstanding feature of the book is the clear presentation of the physics, with easy derivations of the appropriate equations, while emphasizing "rules of thumb" that can be applied by experimental researchers to give semi-quantitative predictions. Presents the fundamental physics underlying many biophotonic applications Reviews the state-of-the-art of interferometric techniques in biology and medicine Serves as a mathematical reference with complete derivations of results Includes numerous graphs and figures to help illustrate interference phenomena.

Biophotometry. --- Biosensors. --- Interference microscopy. --- Interferometry. --- Optical coherence tomography. --- Biophotometry --- Interferometry --- Biosensors --- Interference microscopy --- Optical coherence tomography --- Chemistry Techniques, Analytical --- Tomography, Optical --- Investigative Techniques --- Optical Phenomena --- Radiation, Nonionizing --- Molecular Probe Techniques --- Physical Phenomena --- Radiation --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Tomography --- Phenomena and Processes --- Diagnostic Imaging --- Electromagnetic Phenomena --- Diagnostic Techniques and Procedures --- Diagnosis --- Light --- Tomography, Optical Coherence --- Photometry --- Biosensing Techniques --- Biology --- Physics --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Biology - General --- Light & Optics --- Biophysics --- Optical measurements --- Health aspects. --- Interferometri --- interferens --- optikk --- lys --- optisk diagnose --- medisin --- mikroskopi --- biosensorer --- Biomedisinsk teknikk --- Physics. --- Molecular biology. --- Biophysics. --- Biological physics. --- Optics. --- Optoelectronics. --- Plasmons (Physics). --- Biomedical engineering. --- Biophysics and Biological Physics. --- Biomedical Engineering. --- Optics, Optoelectronics, Plasmonics and Optical Devices. --- Molecular Medicine. --- Physical measurements --- Medicine. --- Biological and Medical Physics, Biophysics. --- Biomedical Engineering and Bioengineering. --- Optics, Lasers, Photonics, Optical Devices. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Clinical engineering --- Medical engineering --- Bioengineering --- Engineering --- Medicine --- Lasers. --- Photonics. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biomolecules --- Systems biology --- New optics --- Optics --- Light amplification by stimulated emission of radiation --- Masers, Optical --- Optical masers --- Light amplifiers --- Light sources --- Optoelectronic devices --- Nonlinear optics --- Optical parametric oscillators --- Biological physics

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"Galileo Unbound traces the journey that brought us from Galileo's law of free fall to today's geneticists measuring evolutionary drift, entangled quantum particles moving among many worlds, and our lives as trajectories traversing a health space with thousands of dimensions. Remarkably, common themes persist that predict the evolution of species as readily as the orbits of planets or the collapse of stars into black holes. This book tells the history of spaces of expanding dimension and increasing abstraction and how they continue today to give new insight into the physics of complex systems.Galileo published the first modern law of motion, the Law of Fall, that was ideal and simple, laying the foundation upon which Newton built the first theory of dynamics. Early in the twentieth century, geometry became the cause of motion rather than the result when Einstein envisioned the fabric of space-time warped by mass and energy, forcing light rays to bend past the Sun. Possibly more radical was Feynman's dilemma of quantum particles taking all paths at once -- setting the stage for the modern fields of quantum field theory and quantum computing. Yet as concepts of motion have evolved, one thing has remained constant, the need to track ever more complex changes and to capture their essence, to find patterns in the chaos as we try to predict and control our world." -- Publisher's description.

Science --- Science, Renaissance. --- Philosophy --- History. --- Galilei, Galileo, --- Criticism and interpretation.

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