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Molecular Defects in Cardiovascular Disease provides an in-depth discussion of the molecular mechanisms underlying the genesis of cardiovascular defects and the implications this has on current and emerging targeted therapeutics.  Divided into three sections, this book covers the scientific foundations of our present understanding as well as the array of clinical manifestations and their treatment.  The first section covers Molecular Mechanisms of Heart Disease, with discussion of the development of cardiovascular dysfunction.  The remaining two sections provide a more clinical focus.  The second, Cardiac Hypertrophy and Heart Failure deals with metabolic derangements, Ca2+ handling, and subcellular remodeling.  It illustrates the wide variety of molecular defects which may serve as targets associated with the transition from cardiac hypertrophy to advanced heart failure.  The third section, Hypertension and Diabetes, provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy, as well as highlighting the importance of hormones toward this end.    A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology.  It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.

Cardiovascular system --- Genetics --- Diseases --- Medicine --- Biochemistry --- Chemistry --- Health Occupations --- Biological Science Disciplines --- Biology --- Natural Science Disciplines --- Disciplines and Occupations --- Molecular Biology --- Pathology --- Cardiovascular Diseases --- Health & Biological Sciences --- Molecular aspects --- Heart --- Abnormalities. --- Diseases. --- Cardiac diseases --- Heart diseases --- Heart defects --- Abnormities and deformities --- Medicine. --- Cardiology. --- Medical biochemistry. --- Medicine & Public Health. --- Medical Biochemistry. --- Cardiology --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Medical sciences --- Internal medicine --- Composition --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry

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Human biochemistry --- Pathological biochemistry --- Pathology of the circulatory system --- biochemie --- cardiologie

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Rapid advances in molecular medicine have led to pronounced new developments in experimental and clinical cardiology.  In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has seen major strides in the understanding of the molecular mechanisms that drive disease progression.  The ability to rapidly identify candidate human genes for cardiovascular diseases lends itself to the development of diverse strategies for disease treatment and management.  The wide variety of gene expressions proffers excellent targets for novel therapeutics.  Gene therapy is steadily increasing in viability and represents a fascinating arena of research and clinical focus.   This book is based on two international Mendel symposia on Genes and the Heart,  joint meetings of the Japanese and European sections of the International Academy of Cardiovascular Sciences.  Highlighting selected symposia contributions, this book explores the role of molecular biology and genetics in the basic knowledge, genesis, and clinical interventions of cardiovascular diseases.

Human biochemistry --- Pathological biochemistry --- Pathology of the circulatory system --- biochemie --- cardiologie